The lack of clinical and laboratory markers that reliably predict response, side effects, or toxicity to therapeutic intervention poses a significant challenge in therapeutic decision-making. Consequently, rheumatologists and other physicians treating patients with rheumatoid arthritis (RA) must choose treatment regimens based on their own experience and assessment of the literature which usual...

BACKGROUND Isolated systolic hypertension (ISH) is a major cardiovascular risk factor. The prevalence of ISH, isolated diastolic (IDH), and mixed hypertension (MH) and their association with lipid, inflammatory, and endothelial cell markers were assessed. METHODS A population sample from Haute-Garonne, France, was chosen. RESULTS Prevalence of ISH, IDH, and MH was 16%, 5%, and 16%, respecti...

OBJECTIVE We conducted a pilot study to evaluate the effects of pelvic radiotherapy on biologic markers of oxidative stress and plasma endotoxin levels, and to assess the relationship between the changes of such factors and radiotherapy-related complications. METHODS Twelve gynecologic cancer patients who were treated via pelvic radiotherapy with or without concurrent chemotherapy were enroll...

background and objective: evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. we have selected renal cell carcinoma (rcc) in this study. to determine tumor proliferative activity, ki67 antibody was applied and results were compared with apoptosis, applying p53 antib...

statement of the problem: odontogenic keratocyst (okc) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion. purpose: the aim of the present study was to determine the mean vascular densities (mvd) of ...

Background and Objective: Evaluation of tumor proliferative activity may provide a predicting parameter to estimate biologic aggression and a subsequent prognosis that has been evaluated in many malignancies. We have selected renal cell carcinoma (RCC) in this study. To determine tumor proliferative activity, KI67 antibody was applied and results were compared with apoptosis, applying P53 antib...

Biologic factors that predict the survival of patients with a diffuse large B-cell lymphoma, such as cell of origin and stromal signatures, have been discovered by gene expression profiling. We attempted to simulate these gene expression profiling findings and create a new biologic prognostic model based on immunohistochemistry. We studied 199 patients (125 in the training set, 74 in the valida...

Hospitalisation and surgery are considered to be markers of more severe disease in Crohn's disease. These are costly events and limiting these costs has emerged as one rationale for the cost of expensive biologic therapies. The authors sought to review the most recent international literature to estimate current hospitalisation and surgery rates for Crohn's disease and place them in the histori...