Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments culturing is usually required to produce enough biomass for investigations of their...

Bristol et al. (1) recently introduced and summarized 17 sets of predictions of the carcino-genicity of 30 chemicals currently undergoing long-term rodent cancer bioassay in the National Toxicology Program (NTP). These predictions will eventually be compared with the bioassay outcomes. To aid that process, a summary table was provided by Bristol et al. (1). In the legend to that summary table, ...

Fluorescence spectroscopy is widely used in chemical and biological research. Until recently most of the fluorescence experiments have been performed in the far-field regime. By far-field we imply at least several wavelengths from the fluorescent probe molecule. In recent years there has been growing interest in the interactions of fluorophores with metallic surfaces or particles. Near-field in...

Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. Recent work in visualisation and data mining has been used to develop structure--activity relationships from such chemical-biological datasets.

A novel strategy for the synthesis of CF-AuNMs by reducing HAuCl(4) with ABEI in aqueous solution at room temperature is reported. No additional stabilizing and reducing reagents are needed, and various morphologies of CF-AuNMs can be obtained. It could be used as bio-probe for bioassays.

We recently developed a new, rapid, and specific bioassay system that employs a fluorescent probe fabricated from our discovered CXCR4-specific ligand DV1. This new probe sensitively and selectively blocks the binding of native and synthetic ligands to CXCR4 at nanomolar levels, with a capability comparable to that seen with a conventional CXCR4 antibody. This nonradioactive, direct, and CXCR4-...

With the technical assistance of Brenda Prewitt T HE ROLE OF ERYTHROPOIETIN in the regulation of normal, steadystate, erythropoiesis in man has been disputed.14 The relative imisensitivity of currently employed technics for the detection of this hormone in normal plasma5 and urine” has contributed to this problem. This report presents sults derived from improvements in the polycythemic mouse bi...

The newest developments in propolis pharmacological research are summarized. The problem regarding biological studies, caused by the chemical variability of propolis, is discussed. The most important trends and developments in recent propolis research are outlined: biological studies performed with chemically characterized samples, bioassay-guided studies of active principles and comparative bi...

2.1.1 General Procedure 5988 2.1.2 Heparin Detection 5992 2.1.3 Carbohydrate Structures 5994 2.2 Lectin-Based Biosensors 5995 2.3 Glycoprotein and Glycosylation Biosensors 5997 2.4 Pathogen and Cancer-Detection Assays 5999 2.4.1 Pathogen Identification 5999 2.4.2 LPS Biosensors 6002 2.4.3 Cancer Diagnostics 6003 2.5 Carbohydrate Nanobiosensors 6003 2.6 Miscellaneous Carbohydrate Bioassays 6004 ...