Different workers have at various times sought to correlate the in vivo and in vitro activities of hyaluronidase preparations. Chain & Duthie (1940), drawing attention to the association between diffusion in the tissues and the mucolytic activity of testicular extracts, pointed out that the viscosityreducing and diffusing activities of various enzyme preparations were in good agreement. McClean...

Recombinant plasminogen activator (reteplase) is a third generation thrombolytic agent which has been used on coronary artery thrombosis and acute myocardial infarction. Clot lysis assay is usually considered as a unique method to evaluate biological activity of reteplase. In this study biological activity of reteplase was determined by APTT (activated partial thromboplastin time) lysis method....