WF14865Aand B, novel cathepsins B and L inhibitors, were produced and isolated separately from the culture mycelium of a fungal strain Aphanoascus fulvescens No. 14865. Spectroscopic analysis revealed that both WF14865Aand B were composed of transepoxysuccinyl moieties, 1 -//-imidazole-2-ylamine, and isoleucine or leucine. These compounds inhibited human cathepsins B and L with IC50 values in t...

Arbutus unedo L. (strawberry tree) has a circum-Mediterranean distribution, being found in western, central and southern Europe, north-eastern Africa (excluding Egypt and Libya) and the Canary Islands and western Asia. Fruits of the strawberry tree are generally used for preparing alcoholic drinks (wines, liqueurs and brandies), jams, jellies and marmalades, and less frequently eaten as fresh f...

The interaction of polymers having the characteristics of synthetic or natural, biocompatible and biodegradable polyelectrolytes with biomolecules exhibits the presence of biologically important mechanisms and has a great importance for biomedical uses. Researches about artificial immunization systems are still continuing thanks to the adjuvant effect which stimulates the immunity and which is ...

Fluothane (halothane BP), one of the purest anaesthetics, contains traces of some impurities amounting to a total of 005 per cent w/w, none of them exceeding 001 per cent w/w. Once these impurities had been identified they were synthesized and tested for anaesthetic activity and toxicity. The results of these experiments showed that most of these impurities have low toxicity but Fluothane conta...

In mammals there are at least 10 isoforms of diacylglycerol kinases (DGK). All catalyze the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA). Among DGK isoforms, DGKε has several unique features. It is the only DGK isoform with specificity for a particular species of DAG, i.e., 1-stearoyl-2-arachidonoyl glycerol. The smallest of all known DGK isoforms, DGKε, is also the only DG...

NUTRACEUTICALS 20 MARCH/APRIL 2013 SUMMARY Green propolis derives mainly from vegetative apices of Baccharis dracunculifolia (alecrim plants). However, wide variation detected in the chemical composition suggests contributions from alternative resin plant sources. Prenylated cinnamic acid-derived compounds bearing prenyl groups are predominant and pharmacologically active components of the resi...

Thuja orientalis (CommonlyMorpankhi, FamilyCupressaceae) is an evergreen, monoecious trees or shrubs used in various forms of traditional medicines and homeopathy in various ways. In traditional practices Thuja is used for treatment of bronchial catarrh, enuresis, cystitis, psoriasis, uterine carcinomas, amenorrhea and rheumatism. Recent researches in different parts of the world have shown tha...

The present study is designed to elucidate certain biological characteristics of urinary chorionic gonadotropin and to see what differences could be demonstrated between HCG in normal pregnancy and in the trophoblastic diseases. We have attempted the biological characterization of HCG using crude HCG and the purified HCG (12 ,000 I.U./mg) by zone electrophoresis on starch grain and chromatograp...