Antibody microarrays enable parallelized and miniaturized analysis of clinical samples, and have proven to provide novel insights for the analysis of different proteomes. However, there are concerns that the performance of such direct labeling and single antibody assays are prone to off-target binding due to the sample context. To improve selectivity and sensitivity while maintaining the possib...

Manganas et al. (Reports, 9 November 2007, p. 980) reported the discovery of a biomarker specific for neural progenitor cells detectable using magnetic resonance spectroscopy. A new algorithm was developed to extract the biomarker from noisy in vivo data. We question how this algorithm was validated, because the biomarker overlaps with peaks from nonspecific lipid signals.

Zusammenfassung Die vorliegende Übersicht zum Biomarker Neurofilament-Leichtketten (NFL) wird im Rahmen der Serie „Biomarker“ des Zentralblatts für Arbeitsmedizin, Arbeitsschutz und Ergonomie publiziert. Das NFL ist ein Serummarker in Diagnostik multiplen Sklerose. eignet sich als Marker zur Therapie‑, Verlaufs- Rezidivkontrolle von multipler Hier zeigt dieser eine hohe Sensitivität Spezifität.

Assessing genetic variation within populations and genetic exchange between populations requires an understanding of the distribution and abundance of individual genotypes within the population. Previous workers have used somatic incompatibility testing to distinguish clones or individuals in natural populations of ectomycorrhizal fungi. However, somatic incompatibility tests performed with iso...

Susceptibility to sporadic Parkinson's disease (PD) is thought to be influenced by both genetic and environmental factors and their interaction with each other. Statistical models including multiple variants in axon guidance pathway genes have recently been purported to be capable of predicting PD risk, survival free of the disease and age at disease onset; however the specific models have not ...

As the detailed reports are pasted below and have also been forwarded to you prior to this email, I will only repeat the main point(s) here. As we have discussed before, two referees (1 and 2) raised concerns about the purity and definition of the different cell types based on established marker gene expression and referee 1 still feels that your explanation does not sufficiently address this p...

The development of early and personalized diagnostic protocols is considered the most promising avenue to decrease mortality from cancer and improve outcome. The emerging microfluidic-based analyzing platforms hold high promises to fulfill high-throughput and high-precision screening with reduced equipment cost and low analysis time, as compared to traditional bulky counterparts in bench-top la...

We analysed the change of spatial genetic structure (SGS) of reproductive individuals over time in an expanding Pinus halepensis population. To our knowledge, this is the first empirical study to analyse the temporal component of SGS by following the dynamics of successive cohorts of the same population over time, rather than analysing different age cohorts at a single time. SGS is influenced b...

In the longitudinal study measurements of various biomarkers are taken from the same set of patients repeatedly over long periods. The longitudinal data provides important temporal information about the development of diseases. When applying standard data mining techniques to perform biomarker analysis and build predictive models to study diseases, typically the important temporal relationship ...