Angiogenesis (the recruitment and formation of new blood vessels) may be a limiting step in the growth of tumors. Recent work in animal models of human cancer suggests that even transient angiogenic signals can irreversibly block tumor dormancy, promoting tumor growth. Another report concludes that the production of an-giogenic factors may result from activation of a signaling pathway in the in...

This Biomedicine Select explores a cluster of recent papers that highlight traditional and new approaches to treating a variety of diseases—from a small-molecule inhibitor to treat temporal lobe epilepsy to cell replacement therapy for diabetes to a unique way to generate tumor-specific antigens. Epilepsy affects more than 50 million people worldwide and about 40% of those with the disease cont...

Departments of Surgery and of Biomedicine, University Hospital Basel, Basel, Switzerland Department of Rheumatology, University Hospital Basel, Basel, Switzerland Department of Biomedicine, Signal Transduction, University Hospital Basel, Basel, Switzerland Orthopaedic Department, Osteoarthritis Research Center, University Hospital Basel, Basel, Switzerland Department of Biomedicine, Development...

Antibiotic-resistant bacteria are a serious threat to human health. A recent study by D’Costa et al. reveals that multidrug-resistant microbes are far more prevalent than previously imagined. This group examined soil microbes for antibiotic resistance. First, they isolated sporeforming bacteria from different environments and then selected the actinomycetes (confirmed by sequencing 16S ribosoma...

Imaging informatics has emerged as a major research theme in biomedicine in the last few decades. Currently, personalised, predictive and preventive patient care is believed to be one of the top priorities in biomedical research and practice. Imaging informatics plays a major role in biomedicine studies. This paper reviews main applications and challenges of imaging informatics in biomedicine.

1) Phrasing techniques have not been fine tuned to the requirements of the biomedicine domain. 2) Most of the phrasing techniques have been based on n-gram models. 3) Research in the area of phrasing and biomedicine specific IR systems has been done in isolation. 4) Due to the diversity of the vocabulary of the biomedicine domain, existing phrasing techniques may not improve query precision. 5)...