نتایج جستجو برای: bis[5
تعداد نتایج: 3 فیلتر نتایج به سال:
AIMS The aim of this study was to examine the effects of bisoprolol (BIS), a selective beta1-adrenoceptor antagonist without partial agonistic activity, on noradrenaline- and phenylephrine-evoked venoconstriction in man using the dorsal hand vein compliance technique. METHODS Twelve healthy male volunteers participated in three weekly experimental sessions. Subjects were allocated to treatmen...
Abstract Background Immune checkpoint inhibitors (ICI) PD-1/PD-L1 antibody are key drugs for the treatment of cancer. Bispecific is one strategies aimed to meet clinical needs cancer patients who resistant or refractory from ICI treatment. TIM-3, next generation targets, co-expressed on exhausted T cells with PD-1. It also expressed by innate immune populations, including NK and DC. Dual blocki...
The X-ray crystal structures were solved for complexes with Torpedo californica acetylcholinesterase of two bivalent tacrine derivative compounds in which the two tacrine rings were separated by 5- and 7-carbon spacers. The derivative with the 7-carbon spacer spans the length of the active-site gorge, making sandwich interactions with aromatic residues both in the catalytic anionic site (Trp84 ...
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