BACKGROUND Bladder cancer is the most frequent genitourinary malignancy in Iran. Environmental and genetic factors are the two factors linked with bladder cancer expansion. The aim of this study was to investigate the role of PTEN gene and environmental risk factors on the progression and prognosis of bladder cancer. METHODS We evaluated 55 tumor specimens and 66 bladder mucosa samples of non...

Recently, two genome-wide association studies identified a significant association between the prostate stem cell antigen (PSCA) rs2294008 (C>T) polymorphism and risk of diffuse-type of gastric cancer in Asians and bladder cancer in Caucasians, respectively. PSCA has been reported highly expressed in bladder cancer and been considered as a useful marker for diagnosis and progression of bladder ...

Purpose: To identify a novel biomarker for bladder cancer targeting therapy. ExperimentalDesign: Thehumanbladder cancer cell line T24 cellswere used as immunogen to generate mouse monoclonal antibodies. We screened and identified a specific antibody BCMab1 against bladder cancer. We examined BCMab1 antigen expression in the patients with bladder cancer through immunohistochemical staining and i...

Invasive bladder cancer has high morbidity and nearly uniform mortality when metastatic, with no therapeutic improvement in many years. Although chemotherapy combined with Chk1 inhibition has been investigated in several cancer types in which TP53 mutation is seen, this combination treatment approach has not been studied in bladder cancer. Recently, cancer genome sequencing efforts have identif...

Purpose: To identify a novel biomarker for bladder cancer targeting therapy. ExperimentalDesign: Thehumanbladder cancer cell line T24 cellswere used as immunogen to generate mouse monoclonal antibodies. We screened and identified a specific antibody BCMab1 against bladder cancer. We examined BCMab1 antigen expression in the patients with bladder cancer through immunohistochemical staining and i...

Bladder cancer is one of most common malignant urinary tract tumor types, and transurethral resection nonmuscle invasive bladder followed by intravesical instillation immunochemotherapy the standard treatment approach to minimize recurrence delay progression cancer. In general, conventional lacks selectivity for tissues effect drug reduced with excretion urine leading frequent administration ir...

Objective: Bladder cancer can be imaged as a sustaining multistage course accumulating genetic and epigenetic changes. Moreover, plenty of studies uncovered that A-to-I RNA editing is an essential part of the growth of normal cells and involved in the variety of biological pathways. To better understand bladder cancer pathogenesis at the molecular level and to uncover novel tumor-initiating eve...

BACKGROUND Bladder cancer is among the five most common malignancies worldwide, and due to high rates of recurrence, one of the most prevalent. Improvements in noninvasive urine-based assays to detect bladder cancer would benefit both patients and health care systems. In this study, the goal was to identify urothelial cell transcriptomic signatures associated with bladder cancer. METHODS Gene...

Bladder cancer is the most common urologic malignancy in China, with an increase of the incidence and mortality rates over past decades. Recent studies suggest that bladder tumors are maintained by a rare fraction of cells with stem cell proprieties. Targeting these bladder tumor initiating cell (TICs) population can overcome the drug-resistance of bladder cancer. However, the molecular and gen...

More than 380,000 new cases of bladder cancer are diagnosed worldwide, accounting for ∼150,200 deaths each year. To discover potential biomarkers of bladder cancer, we employed a strategy combining laser microdissection, isobaric tags for relative and absolute quantitation labeling, and liquid chromatography-tandem MS (LC-MS/MS) analysis to profile proteomic changes in fresh-frozen bladder tumo...