Introduction: The blood-brain barrier (BBB) plays a major role in controlling the microenvironment of the brain. Drug delivery to the brain is restricted by the presence of the BBB. It is actually selectively permeable to nutrients necessary for healthy brain function. Material and Methods: Various search engines like pubmed , medline and cochrane database were searched for various articles. Re...

Blood-brain barrier breakdown worsens ischaemic damage, but it is unclear how molecules breach the blood-brain barrier in vivo. Using the obese ob/ob mouse as a model of enhanced blood-brain barrier breakdown, we investigated how stroke-induced structural changes to the microvasculature related to blood-brain barrier permeability. Ob/ob mice underwent middle cerebral artery occlusion, followed ...

The availability of genome-wide expression data for the blood-brain barrier is an invaluable resource that has recently enabled the discovery of several genes and pathways involved in the development and maintenance of the blood-brain barrier, particularly in rodent models. The broad distribution of published data sets represents a viable starting point for the molecular dissection of the blood...