Do oxygen-derived free radicals, generated at the time of reperfusion, lethally injure viable, previously ischemic myocardium, damage vascular endothelium, and impair recovery of postischemic contractile function? To address these issues, 23 anesthetized open-chest dogs underwent 2 hours of left anterior descending coronary artery occlusion followed by 4 hours of reperfusion. Immediately prior ...

nary artery disease has provided an intense stimulus for expansion of our present knowledge of the coronary circulation. In the experimental animal laboratory, the electromagnetic flowmeter has proved to be an excellent tool by which one can study dynamic aspects of the coronary circulation. A flowmeter is clearly unsuitable for human investigation; therefore, the search for a simple method of ...

Assessment of coronary blood flow and the vasodilator reserve capacity of individual coronary arteries in the catheterization laboratory has been hampered by methodologic limitations. We have developed and validated a small Doppler catheter that can subselectively measure phasic coronary blood flow velocity (CBFV). In seven anesthetized calves, CBFV was varied from 0.1 to 5.7 times control CBFV...

Explicit results concerning blood flow, alveolar blood volume, regional differences, and transit time distribution are derived from the sheet-flow theory and compared with experimental evidence available in the literature. A general consistency is indicated. The theory exhibits in a simple form the effects on flow of the arterial, alveolar, and venous pressures, the alveolar area, the mean path...

Studies have shown that vascular impairment plays an important role in the etiology and pathogenesis of various ocular diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal venous occlusive disease. Thus, qualitative and quantitative assessment of ocular blood flow (BF) is a topic of interest for early disease detection, diagnosis, and management. Owin...

The cardiovascular disease is one of most frequent cause deaths in modern society. The objective of this work is analyse the effect of dynamic vascular geometry (curvature, torsion, bifurcation) and pulsatile blood nature on secondary flow, wall shear stress and platelet deposition. The problem was examined as multi-scale physical phenomena using perturbation analysis and numerical modelling. T...

V0 is the vascular distribution volume for the tracer in the tissue. In bolus type experiments such as H2O PET, this term is significant, whereas for inhalation of Xenon, the vascular term is not generally included, and Vo = 0. To measure CBF, the free parameters in Eq 1 are varied to obtain an optimal fit of the expression to regional uptake curves, using non-linear, least squared regression a...

In addition to many overly restrictive simplifications of this type, the text offers some extraordinary and equally arresting therapeutic suggestions. In 1964, it is intriguing to discover that relief in pericarditis "is often obtained from the application of four or five leeches over the praecordium," that extract of ox gall may help the symptoms of acute hepatitis, and that "Kaolin poultices ...