Diabetes mellitus is the most common metabolic diseases. It is estimated that its worldwide prevalence will reach to 21% up to 2050. In Iran the prevalence of diabetes is estimated to be about 14%. It divided in two categories: type 1 and type 2. Diabetes type 1 is due to absolute deficiency of insulin secretion, and type 2 characterised by resistances to insulin and its inadequate compensation...

Close control of blood glucose levels significantly reduces vascular complications in diabetes, as well as having beneficial effect for cardiac and other critical care patients. Recent studies have shown that tight regulation of blood glucose level in intensive care unit patients can reduce mortality by as much as 45%. This paper presents an optimal insulin infusion algorithm to tightly regulat...

Summary Systemic metabolic homeostasis is regulated by inter-organ cycles involving multiple organs. Obesity impairs cycles, resulting in diseases. The systemic landscape of dysregulated obesity has yet to be explored. Here, we measured the transcriptome, proteome, and metabolome liver skeletal muscle blood fasted wild-type leptin-deficient obese (ob/ob) mice, identifying components with differ...

Four grams of glucose circulates in the blood of a person weighing 70 kg. This glucose is critical for normal function in many cell types. In accordance with the importance of these 4 g of glucose, a sophisticated control system is in place to maintain blood glucose constant. Our focus has been on the mechanisms by which the flux of glucose from liver to blood and from blood to skeletal muscle ...

We have studied edible algae that have the potential to down-regulate blood glucose. In Japan, Ecklonia species have been believed to improve the circulation of blood. In this study, we used leptin receptor deficient type 2 diabetes model mice (db/db) and prediabetic C57BL/6J mice. We also focused on the role of IFN-γ in the control of blood levels of triacylglycerol and glucose, because it is ...

The aim of the study was to evaluate whether intestinal glucoreceptors participate in the regulation of pancreatic islet blood flow. For this purpose, anesthetized rats were infused (0.1 ml/min for 3 min) with saline, glucose, or 3- O-methylglucose directly into the duodenum. The glucose (1 mg/kg body wt) infusion rate was chosen to prevent any effects on systemic or intraportal blood glucose c...

BACKGROUND Adolescents dealing with type 1 diabetes experience disruptions in affect and diabetes management that may influence their blood glucose. PURPOSE A daily diary format examined whether daily fluctuations in both negative and positive affect were associated with adolescents' perceived diabetes task competence (DTC) and blood glucose, and whether perceived DTC mediated the relationshi...

background glucose is an essential element in the supply of body’s energy. in diseases such as diabetes, glucose increase is associated with disturbance in metabolism. cortisol is an important hormone in the regulation of glucose metabolism, and human serum albumin (hsa) is one of the most important glucose and cortisol transmitters in blood. interaction between albumin and these ligands could ...