Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...

A convenient way to estimate internal body time (BT) is essential for chronotherapy and time-restricted feeding, both of which use body-time information to maximize potency and minimize toxicity during drug administration and feeding, respectively. Previously, we proposed a molecular timetable based on circadian-oscillating substances in multiple mouse organs or blood to estimate internal body ...

Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinant human CYP450s yeast cells containing c-DNA expressed P450s was applied to identify the metabolic pathways of iguratimod and to prepare its metabolite. The metabolite was isolated, and its structure was identified by quadrupole time-of-flight-mas...

Background: To determine the atmospheric contamination by pesticides, conducting laboratory studies is necessary before operating field studies. The aim of this research study was to develop an analytical method to sample and simultaneously determine airborne amitraz and its metabolite. Methods: A modified fritted impinger with acetonitrile as the liquid sorbent was used in order to study the...

background: clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet p2y12 adenosine diphosphate receptor. it seems that methadone as cyp2c19 inhibitor affects ticlopidine activity in vivo. this study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics. methods: we conducted a case–control study in 10...

background: to determine the atmospheric contamination by pesticides, conducting laboratory studies is necessary before operating field studies. the aim of this research study was to develop an analytical method to sample and simultaneously determine airborne amitraz and its metabolite. methods: a modified fritted impinger with acetonitrile as the liquid sorbent was used in order to study the a...

an experiment was conducted in algerian desert goats to study the effect of age and season on blood biochemical and mineral profile during different physiological stages of the goats. serum ca, mg and na levels were significantly high at birth and decreases as the age advanced. the season had a significant effect on the decreased levels of ca, mg and k and inversely on the increased levels of n...