Blood analysis is one of the first screening tests used to determine the general status of a person. From such exams it is possible to determine a biochemical analysis of the main metabolites, trace molecular profiles of some organs and evaluate the cellular state of the blood. Among all the important information that can be extracted from the compounds present in the bloodstream, the identific...

P-Glycoprotein (P-gp) has been hypothesized to modulate intestinal drug metabolism by increasing the exposure of drug to intracellular CYP3A through repeated cycles of drug absorption and efflux. The rat single-pass intestinal perfusion model was used to study this interplay in vivo. N-Methyl piperazine-Phe-homoPhe-vinylsulfone phenyl (K77), a peptidomimetic cysteine protease inhibitor (CYP3A/P...

Abstract Purpose The relationship between Hashimoto's thyroiditis and vitamin D concentration was already presented in many studies. aim of this study to analyze the differences metabolites healthy women with (HT). Methods quantitative analysis five carried out using liquid chromatography coupled tandem mass spectrometry. analyzed materials were serum dried blood spots (DBS). results obtained f...

the aim of this experiment was evaluating effect of fish oil versus palm oil on mammary gland health and milk production in holstein cows. ten multiparous holstein cows were used from six week before up to 63 days after parturition. feed intake and milk production were recorded daily, milk composition, body weight and body condition score were measured weekly and blood metabolites were determin...

in order to comprise the effects of sodium bicarbonate supplementation on anaerobic performance and some plasma metabolites, 16 young male athletes (age 20.58?3.25, height 175.33?2.48 cm and bmi 21.57? 2.68 kg/m2) participated in two 400 m running sessions one hour following sodium bicarbonate or placebo (calcium bicarbonate) supplementation with the counterbalanced order. there were three bloo...

A rat model was used to study if postmortem redistribution of the S- and R-enantiomers of citalopram (CIT) and its metabolites demethylcitalopram (DCIT) and didemethylcitalopram (DDCIT) occurs after three different subcutaneous dosing procedures with racemic CIT. Two groups underwent chronic administration (20 mg/kg daily) using osmotic pumps. After 10 days, 1 of these groups received an acute-...