Abstract Blood flow through a vascular bed is usually determined by the pressure gradient across it and diameter of precapillary resistance vessels. Special circulations have additional specific features blood control. Several organs control their supply autoregulation. Coronary linked to myocardial oxygen consumption, primarily metabolic mechanism. Increases in demand or decreases cau...

A great deal of evidence has revealed an important link between gut microbiota and the heart. In particular, plays a key role in onset cardiovascular (CV) disease, including heart failure (HF). HF, splanchnic hypoperfusion causes intestinal ischemia resulting translocation bacteria their metabolites into blood circulation. Among these metabolites, most is Trimethylamine N-Oxide (TMAO), which re...

Introduction Some hydroxy (OH)-metabolites of various PCB congeners such as 4-OH-2,2',3,4',5,5',6-heptachlorobiphenyl (CB187), 4-OH-2,2',3,4',5,5'-hexachlorobiphenyl (hexaCB) (CB146), 4-OH-2,3,3',4',5-pentachlorobiphenyl (CB107), 3'-OH-2,2',3,4,4',5'-hexaCB (CB138) and 3-OH-2,2',4,4',5,5'-hexaCB (CB153) have been found in human blood at higher concentrations. Recent studies have shown that such...

AIM To determine if the diuretic spironolactone cross reacts with 17alpha-hydroxyprogesterone (17OHP) in an enzyme linked immunosorbent assay (ELISA) kit used for the mass screening of congenital adrenal hyperplasia. METHODS Concentrations of 17OHP on a blood filter paper disc were measured using an ELISA kit (kit C-7: ENZAPLATE N-17alpha -OHP-7; Chiron, Tokyo, Japan). The cross reactivity of...

AIM We evaluated the diagnostic value of blood thiamine metabolites for Alzheimer's disease (AD) by using positron emission tomography with 11C-Pittsburgh compound B (11C-PiB PET) scanning. METHODS Thirty-eight clinically diagnosed AD patients were voluntarily recruited. Blood thiamine metabolites were measured by high-performance liquid chromatography. All the patients received 11C-PiB PET s...

Efavirenz (EFV) is one of the most commonly prescribed antiretrovirals for use in the treatment of human immunodeficiency virus (HIV) infection. EFV is extensively metabolized by cytochrome P450 to a number of oxygenated products; however, the pharmacologic activity and distribution of these metabolites in anatomic compartments have yet to be explored. The systemic distribution of EFV oxidative...

OBJECTIVES To determine the kinetics of elimination of urinary dialkylphosphate metabolites after oral and dermally applied doses of the organophosphate pesticide chlorpyrifos to human volunteers and to determine whether these doses affected plasma and erythrocyte cholinesterase activity. METHOD Five volunteers ingested 1 mg (2852 nmol) of chlorpyrifos. Blood samples were taken over 24 hours ...