ABSTRACT The aim of this study was to evaluate the effect inclusion two acidifiers blend (with different protection levels) on acidification potential in vitro, apparent total tract digestibility diet nutrients, blood metabolites, and average daily gain nursery piglets. Two commercial additives (AC1 AC2) were evaluated. added tested by buffering capacity initial pH vitro. For evaluation metabol...

the effect of ethanolic extract of iranian green propolis, rosemary and earthworm meal to determine on performance, immune system and blood metabolites of japanese quail, using 160 mixed-sex quail chicks in a completely randomized design by four treatments (including ethanolic extract of propolis 0.1 percent, rosemary leaves meal 0.5 percent, earthworm meal 0.5 percent and control) and four rep...

Objective(s): The object of the study is to examine the effects of Δ9-tetrahydrocannabinol (THC) against oxidative stress in the blood and excretion of THC metabolites in urine of type 2 diabetic rats. Materials and Methods: The control (n=8), THC control (n=6), diabetes (n=8) and diabetes + THC (n=7) groups were created. Type 2 diabetes was induced by nicotinamide (NA, 85 mg/kg) + streptozotoc...

We used a "high-performance" liquid-chromatographic assay [for parent cyclosporine (CsA) and nine metabolites] and a radioimmunoassay to detail the diversity of results among whole-blood samples from patients with transplanted organs. Heterogeneous populations of metabolites in samples collected just before the next dose of CsA were detected by HPLC, with CsA, M17, M1, or M8 predominating; M21,...

Metabolomics is a promising tool to gain new insights into early metabolic alterations preceding the development of hypertension in humans. We therefore aimed to identify metabolites associated with incident hypertension using measured data of serum metabolites of the European Prospective Investigation Into Cancer and Nutrition (EPIC)-Potsdam study. Targeted metabolic profiling was conducted on...

The isolated perfused rat kidney (IPK) was used to study the acute effects of cyclosporin A (CsA) and its metabolites (M1, M17, M18, M21 and M-COOH). GFR, renal vascular resistance, and sodium, potassium and water reabsorption were measured before and after the addition of CsA/metabolites/vehicles. There was no difference in CsA effect (mild decrease in GFR and increase in renal vascular resist...

the effects of monesin and propylene glycol on feed intake, milk production, and composition as well as some blood metabolites of 16 primiparous and multiparous holstein lactating cows (60±30 days in milk (dim), milk production of 33±3 kg/day) were evaluated. cows were experimentally in a arranged in a randomized complete block design of: 4 feeding treatments, and 2 blocks of either primiparous...