Here we report the synthesis, pharmacological and pharmacokinetic evaluation of a pilot set of compounds structurally related to the potent and selective 5-HT7 ligand LP-211. Among the studied compounds, N-pyridin-3-ylmethyl-3-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]ethoxy]propanamide (4b) showed high affinity for 5-HT7 receptors (K(i)=23.8 nM), selectivity over 5-HT1A receptors (>50-fold)...

AIMS We examined the individual association between body mass index (BMI) and cognitive function among the very elderly. METHODS The present study analyzed data from a survey that was conducted on all residents aged 90 years or more from a district which had 2,311,709 inhabitants in 2005. The subjects were divided into 4 groups according to quartiles of BMI (<16.6, 16.6-18.9, 18.9-21.1 and >2...

Background: Employees are considered as an at-risk group for obesity and its adverse outcomes, particularly cardiovascular diseases (CVD). The present study was conducted to assess the correlation of obesity indices with CVD risk factors among a group of medical university employees in Zahedan city, southeast of Iran. Methods: This cross-sectional study recruited 211 healthy employees of Zaheda...

Background. Few studies have measured, using validated scales, the psychosocial handicap of epilepsy in a general practice setting. Aim. To assess the prevalence of psychosocial problems associated with epilepsy. Method. A survey was undertaken of 309 subjects, with one or more non-febrile epileptic seizures, drawn from two general practices in the United Kingdom (UK). The outcome measures were...

Background: The period of Covid 19 epidemic effect not only illness people but also human lives. A lot People, participating some activities in gym center from Kayseri. Some restraint during the covid by ministry interior was affected who went to fitness center. This situation Body Weight, Mass Index, Fat Index unfavorable. Aim: purpose this study determine physical changes participants activel...

BACKGROUND The role of an elevated body mass index (BMI) in asthma remains controversial. OBJECTIVES To investigate the relationship between overweight (BMI >25 and ≤30), lung function, disease control, and airway inflammation in an asthmatic population. METHODS We consecutively studied 348 patients (age 43 ± 16 years; 211 females). In all patients, BMI, spirometry, the Asthma Control Test ...

Materials and methods The study analyzes collected data of a consecutive series of 211 patients submitted to groin hernia repair with open technique, under local anaesthesia. Inclusion criteria were: primary groin hernia, BMI < 30 and good home support. All patients were preoperatively assessed on their ASA grade. Then they were retrospectively divided in two groups, over 70 year-olds and young...