Stem cell-based tissue engineering shows promise for bone regeneration and requires artificial microenvironments to enhance the survival, proliferation and differentiation of the seeded cells. Silk fibroin, as a natural protein polymer, has unique properties for tissue regeneration. The present study aimed to evaluate the influence of porous silk scaffolds on rat bone marrow stem cells (BMSCs) ...

A great deal of research is ongoing in the area of tissue engineering (TE) for bone regeneration. A possible improvement in restoring damaged tissues involves the loading of drugs such as proteins, genes, growth factors, antibiotics, and anti-inflammatory drugs into scaffolds for tissue regeneration. This mini-review is focused on the combination of the local delivery of antibiotic agents with ...

Osteoarthritis (OA) is a common chronic degenerative disease. The prevalence tends to increase with age and influenced by underlying risk factors such as gender, obesity, joint injuries (work/sports activities), geographic region. OA has distinctive picture, namely, damage the cartilage formation of new bone at edges bones, also called osteophytes, due biochemical, metabolic, physiological, pat...

Biomineralization Article 2200976 by Luiz E. Bertassoni and co-workers presents injectable cell-laden bone-like tissue constructs that show promise as minimally invasive growth factor-free alternatives to bone autografts for repair regeneration of critical sized defects. By approximating the cellular, structural, chemical composition native bone, engineered microconstructs promote native-like m...

Current strategies for skeletal regeneration involve the use of autogenous and allogenic bone grafts that may not always be available or safe to use. One alternative is to develop materials for use as scaffolds for the tissue engineering of bone. We created architecturally nanofibrous scaffolds using the electrospinning technique. These calcium phosphate- based materials are porous, have a larg...

Stimulating bone growth and regeneration, especially in patients with delayed union or non-union of bone, is a challenge for orthopaedic surgeons. Treatments employed for bone regeneration are based on the use of cells, biomaterials and factors. Among these therapies, cell treatment with mesenchymal stem cells (MSCs) has a number of advantages as MSCs: (1) are multipotent cells that can migrate...