Bone metastases are common, especially in more prevalent malignancies such as breast and prostate cancer. They cause significant morbidity draw on health-care resources. Molecular hybrid imaging techniques, including SPECT/CT, PET/CT, whole-body MRI with diffusion-weighted imaging, have improved diagnostic accuracy staging the skeleton compared previous standard methods, allowing earlier tailor...

   Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obt...

The increasing evidence of oncocytic renal tumors positive in 99mTc Sestamibi Single Photon Emission Tomography/Computed Tomography (SPECT/CT) examination calls for the development diagnostic tools to differentiate these from more aggressive forms. This study combined radiomics analysis with uptake on SPECT/CT benign neoplasms cell carcinoma. A total 57 were prospectively collected. Histopathol...

Abstract Aims The prognostic role of bone tracer uptake in transthyretin cardiac amyloidosis (ATTR-CA) is controversial. study investigated the potential significance biventricular (BiV) ATTR-CA. Methods Consecutive ATTR-CA patients who had scintigraphy with acquisition planar and single-photon emission computed tomography (SPECT) images from National Amyloidosis Centre (NAC) four Italian centr...

UNLABELLED The purpose of this study was to evaluate the usefulness in a clinical setting of iodine-123-metaiodobenzylguanidine (123I-MIBG) scintigraphy, planar and single photon emission computed tomography (SPECT) images, in patients with neuroblastoma as detected by a mass screening survey. METHODS 123I-MIBG planar whole body images, and regional SPECT images of patients with neuroblastoma...

UNLABELLED We present a new rodent SPECT system (U-SPECT-II) that enables molecular imaging of murine organs down to resolutions of less than half a millimeter and high-resolution total-body imaging. METHODS The U-SPECT-II is based on a triangular stationary detector set-up, an XYZ stage that moves the animal during scanning, and interchangeable cylindric collimators (each containing 75 pinho...

Bone and soft tissue disease is kind of detrimental disease and the precise diagnosis and timely therapy is also the clinical doctors’ object of a prolonged endeavour. This chapter will introduce the diagnostic and therapeutic methods of bone and soft tissue diseases with nuclear medicine techniques. The singular advantages of skeletal scintigraphy are high sensitivity in detecting early diseas...

An early diagnosis of bone metastasis is very important for making a right decision on a subsequent therapy. One of the most important steps to be taken initially, for developing a new radiopharmaceutical is the measurement of organ radiation exposure dose. In this study, the dosimetric studies of a novel agent for SPECT-imaging of the bone metastasis, 111In-(4{[(bis(phosphonomethyl))carbamoyl]...