This paper discusses the use of Box Behnken design approach to plan the experiments for turning Inconel 718 alloy with an overall objective of optimizing the process to yield higher metal removal, better surface quality and lower cutting forces. Response Surface methodology (RSM) has been adopted to express the output parameters (responses) that are decided by the input process parameters. RSM ...

This paper presents the micro-finishing of bevel gears by electrochemical-mechanical finishing (ECMF) process under different experimental conditions of current, rotating speed of workpiece and electrolyte concentration. These different experimental conditions are planned on the basis of box behnken design (BBD) design of experiments (DOE) technique of response surface methodology (RSM). An emp...

The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...

Purpose: To study the effect of some factors on the size of finasteride nano-emulsion by chemometric approach which could predict the size of nano-emulsion droplets under different conditions. Methods: Nano-emulsions were prepared using spontaneous emulsification method which occurs when organic and aqueous phases are mixed. The organic phase was a homogeneous solution of oil (finasteride as a ...

This study was aimed at developing a polymeric drug delivery system for a steroidal aromatase inhibitor, exemestane (exe) intended for sustained targeted delivery of drug through intravenous route. Carboxylated polycaprolactone (cPCL) was synthesized by ring opening polymerization of caprolactone. Exe-loaded cPCL nanoparticles (NPs) were prepared by interfacial deposition of preformed polymer a...