The extraction of lutein and β-carotene from spinach (Spinacia oleracea L.) leaves is important to the dietary supplement industry. A Box-Behnken design and response surface methodology (RSM) were used to investigate the effect of process variables on the ultrasound-assisted extraction (UAE) of lutein and β-carotene from spinach. Three independent variables, extraction temperature (°C), extract...

The polyurethane membrane is used as a separator either by filtration or adsorption, and this process significantly affected its strength physical condition. We synthesized membranes using red seaweed with Gracilaria sp hydroxyl source. Box-Behnken Design of the Response Surface Methodology (RSM) Software Expert Version 10.0.3.0 three factors (TRL, TDI, Glycerin). F-value 0.42 suggests that les...

- Missing observations occur in experimental designs as a result of insufficient sampling, machine breakdown, high cost, and errors in the measurements. In nanomanufacturing, missing observations often appear in designs because the combination of factors or molecular structures selected by a designer cannot be experimented successfully. In the current paper, Box-Behnken and face-centered compos...

objective(s): a box-behnken design was used for evaluation of eudragit coated diclofenac pellets. the purpose of this work was to optimize diclofenac pellets to improve the physicochemical properties using experimental design. materials and methods: diclofenac was loaded onto the non-pareil beads using conventional coating pan. film coating of pellets was done at the same pan. the effect of pla...

Protein isolates of pumpkin (Cucurbita pepo L) seeds were hydrolyzed by acid protease to prepare antioxidative peptides. The hydrolysis conditions were optimized through Box-Behnken experimental design combined with response surface method (RSM). The second-order model, developed for the DPPH radical scavenging activity of pumpkin seed hydrolysates, showed good fit with the experiment data with...

The natural coagulant Moringa oleifera (MO) is considered to be an efficient coagulant with some advantages over chemical coagulants. Fluoride removal, using MO seed extract was investigated. The influence of MO dosage, initial F concentration, and pH were determined and modeled using the Box-Behnken design response surface methodology. With a constant initial F concentration, it was found that...