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objective: following traumatic brain injury, disruption of blood-brain-barrier and consequent brain edema are critical events which might lead to increasing intracranial pressure (icp), and nerve damage. the current study assessed the effects of aqueous date fruit extract (adfe) on the aforementioned parameters. materials and methods: in this experimental study, diffused traumatic brain injury ...

this study was designed to develop a modified tbi weight drop model for induction of focal mild cerebral injury. a stereotaxic coupled weight drop device was designed. principle arm of device carries up to 500g weights which their force was conveyed to animal skull through a thin nail like metal tip. to determine the optimal configuration of the device to induce mild tbi, six different trials w...

brain edema plays an important role in secondary tissue damage following traumatic brain injury (tbi) but the underlying mechanisms are not entirely elucidated. the g protein coupled receptor fm-4 and its ligands, neuromedin s (nms) and neuromedin u (nmu), are expressed in diverse brain areas, and have a variety of roles in nociception, inflammation, and stress but their probable changes after ...

traumatic brain injury resulting road accidents create damage to the brain. the severe brain injury may cause extensive tissue loss of several parenchyma which results in cavities due to primary destruction and secondary injuries such as ischemia and inflammation. recent findings suggest that neuronal precursors in the adult mammalian brain can be a therapeutic target in ischemic brain injuries...

objective: to determine the effects of pre-injury consumption of anti-platelet agents on the 30-day outcomes of patients with mild traumatic brain injury (tbi). methods: this prospective cohort study was conducted at three general hospitals in tehran, iran between july 2013 and july 2014. the study population included all patients with mild tbi aged over 18 years that medicated with aspirin or ...

traumatic brain injury (tbi) is described by a disruption in the normal function of the brain due to an injury following a trauma, which can potentially cause severe physical, cognitive, and emotional impairment. the use of human stem cells and self-assembling peptide scaffolds suggest huge potential for application in the treatment of tbi. in the present study, we surveyed the beneficial effec...

background cerebral state index (csi) is derived from electroencephalograms to monitor the level of consciousness during anesthesia. some evidence shows that this indicator has been used to detect cerebral ischemia and prognostic outcomes for traumatic brain injury (tbi). objectives the present study was designed to investigate the correlation between glasgow coma score (gcs) and csi for brain-...

traumatic basal ganglia hematoma is a rare condition defined as presence of hemorrhagic lesions in basal ganglia or adjacent structures suchas internal capsule, putamen and thalamus. bilateral basal ganglia hematoma are among the devastating and rare condition. we herein report a 28-year old man, a victim of car-car accident who was brought to our surgical emergency room by immediate loss of co...

traumatic brain injury (tbi) is one of the major causes of severe disability and death in the entire world that accidents are mentioned as main factors of it. tbi lead to primary and secondary injuries.  primary injuries are created immediately after accidents or bleeding but the secondary injuries are created by complicated process of cellular and molecular responses following primary injury a...