conclusions according to our results, silymarin injection caused significant differentiation of mscs to neurons and neuroglia that could be a promising approach for treating a variety of brain injuries. results expression of cd29 and cd90 markers that are characteristic of bmmscs were confirmed by flow cytometry experiments. the data demonstrated that proliferation and number of progenitor cell...

Objective(s):Melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.Secondary injury following the primary traumatic brain injury (TBI) results in glial cells activation, especially astrocytes. In fact, astrocyte activation causes the production of pro-inflammatory cytokines...

Many complicated mechanisms are involved in brain ischemia and the role of inflammatory factors in the progression of post-ischemic injury is inevitable. In present study, anti-inflammatory effect of berberine has been investigated in reperfusion injury after acute ischemic stroke. Male Wistar rats weighing 250-270 gr were randomly divided into four cohorts: healthy rats (control, n=20), sham-o...

Traumatic Brain Injury (TBI) is the most prevalent of all head injuries. Microglia play an essential role in homeostasis and diseases central nervous system. We hypothesize that microglia may a beneficial or detrimental TBI depending on their state activation duration. In this study, we evaluated whether results spatiotemporal change phenotype it affects sensory-motor learning memory functions ...

Background: The present study assesses independent predictors of clinically important traumatic brain injury (ciTBI) in order to design a prognostic rule for identification of high risk children with mild head injury. Materials and Methods: In a retrospective cross-sectional study, 3,199 children with mild traumatic brain injury (TBI) brought to emergency ward of three hospitals in Tehran, Iran...

Background & Aim: Anxiety is one of the most common psychiatric disorders in the family of patients with traumatic brain injury. This study aimed to determine the effect of providing information about the patient’s condition on the anxiety level of the family members of hospitalized patients with traumatic brain injury. Methods & Materials: This quasi-experimental study was conducted on 90 fam...

post-traumatic epileptic seizure is a common complication of brain trauma including military injuries. we present clinical characteristics and correlates of post-traumatic epilepsy in 163 head-injured veterans suffering from intractable epilepsy due to blunt or penetrating head injuries sustained during the iraq-iran war. the medical records of 163 war veterans who were admitted by the epilepsy...

background cerebral state index (csi) is derived from electroencephalogram (eeg) and is used for monitoring the level of consciousness during anesthesia. this study was designed to investigate the accuracy of glasgow coma scale (gcs) and csi as a predictor of in-hospital mortality in patients with trauma brain injury (tbi). objective to compare the predictive value of gcs and csi for predicting...

objective: to evaluate and describe the sleep quality in seven subscales among the patients with mild traumatic brain injury (tbi) and compare it with normal patterns. methods: this cross-sectional study was conducted within a 6-month period from february to august 2014 in shahid rajaei trauma center of shiraz. participants were selected randomly from all adult (18-60 years of age) patients adm...

objective(s):hyperglycemia worsens the neuronal death induced by cerebral ischemia. previous studies demonstrated that diabetic hyperglycemia suppressed the expression of heat shock protein 70 and 60 (hsp70 and 60) in the liver. igg antibody titres against heat shock protein 27 (anti hsp27) were measured to determine whether hyperglycemia exacerbates ischemic brain damage by suppressing the exp...