Objective. Evaluation of changes in the content ATP synthase parietal cortex and hippocampus brain rats with ischemia varying severity a comparative aspect. Methods. The experiments were performed on 88 male outbred white weighing 260 ± 20 g. Brain was modeled under conditions intravenous thiopental anesthesia (40-50 mg / kg). Total cerebral by decapitation animals. sampling carried out 1 hour ...

traumatic brain injury is a common entity. however cerebral infarction in infants is a rare entity while the diagnosis of this pathology in the pediatric population is usually difficult. the mild head trauma is rarely accompanied by intracranial injury and even less, with cerebral infarction. we herein report the first case of cerebral infarction after a mild brain trauma in a 2-year-old latin-...

background: angiotensin ii (ang ii) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. this study evaluated the role of central ang ii by using candesartan, as an at1 receptor blocker, in the brain edema formation and blood-brain barrier (bbb) disruption caused by ischemia/reperfusion (i/r) injuries in rat. methods...

Impaired blood-brain barrier function represents an important component of hypoxic-ischemic brain injury in the perinatal period. Proinflammatory cytokines could contribute to ischemia-related blood-brain barrier dysfunction. IL-6 increases vascular endothelial cell monolayer permeability in vitro. However, contributions of IL-6 to blood-brain barrier abnormalities have not been examined in the...

The general failure of neuroprotectants in clinical trials of ischemic stroke points to the possibility of a fundamental blind spot in the current conception of ischemic brain injury, the "ischemic cascade". This is the first in a series of four papers whose purpose is to work towards a revision of the concept of brain ischemia by applying network concepts to develop a bistable model of brain i...

Electron paramagnetic resonance (EPR) spectroscopy was used to record the content of nitric oxide (NO) and copper in brain tissues (frontal lobes hippocampus) liver healthy rats after ischemia modeling. Ischemia simulated by ligation carotid arteries, followed taking 3 ml blood from common artery. Signals triple complexes (DETC) were recorded EPR (DETC)2-Fe2+-NO Cu(DETC)2. Based on direct measu...

Abstract Zinc ion is essential for normal brain function that modulates synaptic activity and neuronal plasticity it associated with memory formation. considered to be a contributing factor the pathogenesis of ischemia, but association between zinc ischemia on vesicular exocytosis unclear. In this study, we used combination chemical analysis methods cell model ischemia/reperfusion investigate e...

Aims:Memory deficit is the most visible symptom of cerebral ischemia. The hippocampus is sensitive against cerebral ischemia. Oxidative stress and inflammation are involved in the pathological process after cerebral ischemic injury. Paroxetine has anti-oxidative and anti-inflammatory effects. In this study the effect of paroxetine on memory deficit after cerebral ischemia was investigated. Meth...

Brain ischemia leads to muscle inactivity-induced atrophy and may exacerbate motor function deficits. Intramuscular insulin-like growth factor I (IGF-I) injection has been shown to alleviate the brain ischemia-induced muscle atrophy and thus improve the motor function. Motor function is normally gauged by the integrity and coordination of the central nervous system and peripheral muscles. Wheth...

BACKGROUND AND PURPOSE Angiotensin-converting enzyme inhibitors have been shown to protect against stroke in hypertensive rats and to improve neurological outcome after cerebral ischemia in normotensive rats. The present study was designated to test the hypothesis that blockade of brain AT(1) receptors improves the recovery from focal cerebral ischemia and reduces expression of AP-1 transcripti...