Background: Some studies highlighted the role of Jujuboside A as a potent antioxidant on ischemic neurons. However, definitive effect this substance change in expression neuroprotective genes has not been clearly identified. Therefore, study aimed to investigate effects proliferation-inducing and cell count enhancement hippocampus after induction transient global ischemia/reperfusion. Materials...

BACKGROUND The authors' previous study demonstrated that a clinical antiarrhythmic dose of lidocaine, when given before ischemia, is neuroprotective in a rat model of transient focal cerebral ischemia. In this study, the authors investigated whether the administration of this dose of lidocaine, when delayed until 45 min after the onset of ischemia, also reduces ischemic brain injury. METHODS ...

We measured brain tissue Po2 in the frontal and occipital cortices, mid-brain and basal ganglia in monkeys for up to 5 hours after 16 min global brain ischemia to gain some insight into those factors responsible for the selective vulnerability of the brain to ischemic anoxia. Brain tissue Po2 measurements were made with gold microelectrodes with tip diameters of 5 to 10 nm. Reoxygenation of the...

Background: Angiotensin II (Ang II) has an important role on cerebral microcirculation however, its direct roles in terms of ischemic brain edema need to be clarified. This study evaluated the role of central Ang II by using candesartan, as an AT1 receptor blocker, in the brain edema formation and blood-brain barrier (BBB) disruption caused by ischemia/reperfusion (I/R) injuries in rat. Methods...

Introduction: Using brief episodes of ischemia and reperfusion (IR) prior to a more sustained IR insult – ischemic preconditioning (IPC) – can reduce IR injury of the heart, brain and many other tissues. The purpose of present study was to investigate the effect of 2min ischemic periods on subsequent rat renal IR injury. Methods: Male rat's renal IR injury was investigated in a right nephrectom...

To investigate if spontaneous ischemic events in mice with severe multi-organ atherosclerosis could adapt to ischemia, apolipoprotein E/LDL receptor knockout mice were fed an atherogenic diet for 7 to 9 months. Signs of spontaneous ischemia occurred. One to two days later, hearts were excised, Langendorff-perfused with induced global ischemia, and compared with mice without signs of disease. In...

BACKGROUND Rat brain perfusion models are critical to basic research, but they can be imprecise and/or not durable for extended outcome studies. OBJECTIVE To demonstrate a rat brain perfusion model that provides a simplified reliable brain perfusion circuit, reduces variables during experiment and recovery, and therefore permits more precise, reliable, and context-independent research data. ...

Ischemic stroke is caused by the interruption of cerebral blood flow that leads to brain damage with long-term sensorimotor deficits. Stem cell transplantation may recover functional deficit by replacing damaged brain. In this study, we attempted to test whether the human neural stem cells (NSCs) can improve the outcome in the rat brain with intravenous injection and also determine the migratio...