This study was undertaken to determine if advanced epithelial ovarian cancer was associated with increased serum and ascitic levels of soluble interleukin-2 receptor alpha (sIL-2R alpha). Serum and ascitic fluid samples from 23 ovarian cancer patients were analyzed for sIL-2R alpha using an enzyme-linked immunosorbent assay and compared with the serum and peritoneal levels in 18 normal females....

BACKGROUND The soluble interleukin-2 receptor (sIL-2R, sIL2R, sTAC, sCD25) is a reliable biomarker for disease activity in inflammatory disorders such as sarcoidosis. Based on the essential pathogenic role of inflammation for progression of liver diseases, we hypothesized that sIL-2R might be an indicator of inflammatory cell activation and disease severity in patients with chronic liver diseas...

Up-regulation of insulin-like growth factor 2 receptor (IGF-2R) involved in angiotensin II-induced cell apoptosis in cardiomyoblasts, and correlated with cardiomyocyte apoptosis in hypertensive rat hearts. Here, we detected IGF-2R levels and explored the possible underlying implications in end-stage heart failure (HF) patients before and after heart transplantation. Western blot and immunohisto...

The nucleus tractus solitarii (NTS), located in the brainstem, is one of the main nuclei responsible for integrating different signals in order to originate a specific and orchestrated autonomic response. Antihypertensive drugs are well known to stimulate alpha(2)-adrenoceptor (alpha(2R)) in brainstem cardiovascular regions to induce reduction in blood pressure. Because alpha(2R) impairment is ...

A new fossil myrmicine ant genus and species Lelejus venustus gen. et sp. nov. , are described from late Eocene Rovno amber (Priabonian, 33.9–37.8 Ma). This differs all extant extinct Myrmicinae genera known the European ambers in combination of morphological features, particular: 13-segmented antennae with a very short scape filiform funiculus; 3-segmented maxillary 2-segmented labial palps; w...

A graph is called radially maximal if it not complete and the addition of any new edge decreases its radius. In 1976 Harary Thomassen proved that radius $r$ diameter $d$ satisfy $r\le d\le 2r-2.$ Dutton, Medidi Brigham rediscovered this result with a different proof in 1995 they posed conjecture converse true, is, are positive integers satisfying 2r-2,$ then there exists $d.$ We prove little mo...

We prove the nonexistence of a distance-regular graph with intersection array {74,54,15;1,9,60} and of distance-regular graphs with intersection arrays { 4r3 + 8r2 + 6r + 1,2r(r + 1)(2r + 1),2r2 + 2r + 1;1,2r(r + 1), (2r + 1)(2r2 + 2r + 1)} with r an integer and r 1. Both cases serve to illustrate a technique which can help in determining structural properties for distance-regular graphs and as...

A path-matching of order p is a vertex disjoint union nontrivial paths spanning vertices. Burr and Roberts, Faudree Schelp determined the 2-color Ramsey number path-matchings. In this paper we study multicolor Given positive integers r,p1,…,pr, define RPM(p1,…,pr) to be smallest integer n such that in any r-coloring edges Kn there exists color i at least pi for some i?[r]. Our main result r?2 p...

We investigated the clinical value of measuring serum concentrations of soluble IL-2R in monitoring sarcoidosis. Serum concentrations of soluble IL-2R were measured in 70 patients with sarcoidosis. The mean value for active untreated sarcoidosis was 1,143 +/- 509 U/ml, while the normal range in 97 healthy control subjects was 80 to 300 U/ml. The mean value for active untreated sarcoidosis was s...

The synthesis of (2R)-2-methyl-4,5-dideoxy and (2R)-2-methyl-4-deoxy analogues of 6-phosphogluconate is described. The synthetic strategy relies on the Evans aldol reaction for the installation of the chiral centres in the 2- and 3-positions. The selective phosphorylation at the primary alcohol function of (2R,3S)-3,6-dihydroxy-2-methylhexanoic acid benzyl ester (5) and (2R,3S,5S)-3,5,6-trihydr...