In addition to the indirect and direct costs presented, BRL 917 millions are spent annually with loss of income due to premature death (Table 5). The estimated total amount of potential life years lost was 33,898 years (from the average number of deaths over the years 2012, 2013 and 2014). The maximum age rate was used in a conservative way, to not overestimate the number of days lost due to pr...

The sugar-binding specificities of C-type lectins isolated from marine invertebrates were investigated by frontal affinity chromatography (FAC) using 100 oligosaccharides. The lectins included BRA-2 and BRA-3, multiple lectins from the hemolymph of the acorn barnacle, Megabalanus rosa, and BRL from the acorn barnacle, Balanus rostatus. The diverse sugar-binding specificities of the C-type lecti...

the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

The phthalidyl ester (BRL.8988, talampicillin) of ampicillin gave serum levels in man two and a half times those obtained with ampicillin itself.

Cells of the tyrosine aminotransferase (EC 2.6.1.5)-inducible line, HTC, were fused with those of the BRL-62 line, which contain little or no enzyme and are unresponsive to the usual steroid inducers. Histochemical examination of the resulting heterokaryons within 24 hr of the fusion showed them to have little or no enzyme and to be unresponsive to steroids. These experiments disclose that the ...

Abstract With increasing urbanization and critical issues of food insecurity emerging globally, urban agriculture is expanding as an agroecosystem with a distinct soil type. Growing in cities challenged by legacy contaminants soils, which necessitates the use imported, safe soils composts. To promote long-term sustainability agriculture, we examined agronomic potential constructing safe, locall...

BACKGROUND Vinegar-baked Radix Bupleuri (VBRB) enhances the effects of other drugs on the liver by increasing drug distribution to the liver, but the mechanism of action remains unclear. The present study was designed to determine the effects of VBRB on the membrane permeability, constituents, and P-glycoprotein (P-gp) activity of hepatocyte BRL cells, in order to interpret the liver targeting ...

Intelligent traffic light control (ITLC) aims to relieve congestion. Some multi-agent deep reinforcement learning (MADRL) algorithms have been proposed for ITLC, and most of them use neural networks make decisions. However, the abundant parameters structure lead time-consuming training process MADRL. Recently, a broad (BRL) approach has improve efficiency an agent. Unlike MADRL that architectur...

BACKGROUND Liver ischemia reperfusion (I/R) injury is a common pathophysiological process in many clinical settings. Carvacrol, a food additive commonly used in essential oils, has displayed antimicrobials, antitumor and antidepressant-like activities. In the present study, we investigated the protective effects of carvacrol on I/R injury in the Wistar rat livers and an in vitro hypoxia/restora...

Aims: To study RBL-2H3 cell degranulation phenomena induced by some TCMIs through cell morphological and ultra-structural observation, released enzyme activity and establish RBL-2H3 cell degranulation test indicated by βhexosaminidase activity as a method to evaluate TCMIs at nonclinical stage. Methods: RBL-2H3 cells were used to study the degranulation by co-culture with positive control C48/8...