This study determined the in vitro activity of finafloxacin against panels bacterial strains, representative those associated with infection cystic fibrosis patients and predominately isolated from clinical cases respiratory disease. Many these isolates were resistant to various antimicrobials evaluated including aminoglycosides, cephalosporins, carbapenems fluoroquinolones. Broth microdilution...

The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC(90)s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all /=3.13 microg...

We performed bedaquiline broth microdilution susceptibility testing using Clinical and Laboratory Standards Institute (CLSI) guidelines on 103 respiratory isolates of Mycobacterium avium complex (MAC), including multidrug-resistant isolates. Approximately 90% of isolates had bedaquiline MICs of ≤0.008 μg/ml, and 102/103 isolates had MICs of ≤0.015 μg/ml. Bedaquiline has excellent potential for ...