TSC22D1, which encodes transforming growth factor beta-stimulated clone 22 (TSC-22), is thought to be a tumor suppressor because its expression is lost in many glioblastoma, salivary gland, and prostate cancers. TSC-22 is the founding member of the TSC-22/DIP/Bun family of leucine zipper transcription factors; its functions have not been investigated in a multicellular environment. Genetic stud...

Urea rebound refers to an early postdialysis phenomenon in which urea returns to the systemic circulation, raising the blood level to a near plateau over a period of 0.5 to 1 hour [1]. The urea involved is believed to have come from either the intracellular compartment by means of diffusion resulting from the dialysis-induced concentration gradient [2,3], or tissues poorly perfused as a result ...

INTRODUCTION The decision of when to start dialysis in Acute Kidney Injury (AKI) patients with overt uremia is strongly established, however, when blood urea nitrogen (BUN) levels is < 100 mg/dL the timing of initiation of dialysis remains uncertain. PURPOSE The aim of this study was to assess mortality and renal function recovery AKI patients started on dialysis at different BUN levels. ME...

PURPOSE The aims of our study were to evaluate the blood urea nitrogen to creatinine ratio (BUN/Cr ratio) for distinguishing between an upper and lower gastrointestinal bleeding (GIB), and differentiating between the two most common causes of upper gastrointestinal bleeding (UGIB) presenting with melena in children. METHODS Retrospective data of patients with GIB presenting with melena were a...

INTRODUCTION A serological and entomological investigation was performed to monitor for potential Bunyamwera (BUN) serogroup virus activity in Montana. RESULTS To facilitate the serological investigation, sera were collected from 104 sheep in 2013 and 2014 and assayed by plaque reduction neutralization test using all six BUN serogroup viruses known to occur in the United States: Cache Valley ...

Background—Identifying reversible renal dysfunction (RD) in the setting of heart failure (HF) is challenging. The goal of this study was to evaluate if an elevated admission blood urea nitrogen to creatinine ratio (BUN/Cr) could identify decompensated HF patients likely to experience improvement in renal function (IRF) with treatment. Methods and Results—Consecutive hospitalizations with a disc...

BACKGROUND Cisplatin (cis-diamminedichloroplatinum II; CP) is used widely as an antitumor drug in clinics, but is accompanied with renal toxicity. Cisplatin induced nephrotoxicity consists of change in kidney weight, histological changes in kidney and increase in serum creatinine (Cr) and blood urea nitrogen (BUN). This study was designed to find out a model for prediction of cisplatin induced ...

Patients with chronic kidney disease and heart failure (HF) have been shown to be at higher risk for major adverse cardiovascular events and death. Recent studies have demonstrated that blood urea nitrogen (BUN) might serve as a powerful predictor of mortality in acutely decompensated HF. The goal of this study was to determine the impact of BUN on long-term mortality in patients with stage B a...