BACKGROUND Ketamine has been used as an analgesic adjuvant with morphine in the treatment of refractory cancer pain recently. But both morphine and ketamine have been reported to produce a number of immunomodulatory effects. The current study was performed to assess whether the concentration of ketamine, as adjuvant analgesics for patient with refractory cancer pain, was related to its effect o...

BACKGROUND AND OBJECTIVE High-dose cytarabine (HDAra-C), mitoxantrone and etoposide are the mainstay of several active regimens against relapsed or refractory acute myelogenous leukemia (AML). We designed a phase II study to assess the efficacy and side effects of a time sequential application of mitoxantrone plus intermediate-dose Ara-C followed by HDAra-C plus etoposide (GEMIA) in adult patie...

The effect of heat treatment on the mechanical properties and microstructure refractory nickel alloy GH3536 obtained by selective laser melting is determined. Growth in quenching temperature accompanied lowering ultimate strength yield limit under static tension, while elongation increases. After 1-h from 1100°C 10-h aging at 700°C fracture behavior changes brittle one to ductile one, hardness ...

The Esfordi phosphate concentrate mainly contains fluorapatite, monazite, and xenotime as rare earth element (REE) minerals, accounting for 1.5% of rare earth metals. The monazite and xenotime minerals are refractory and their decomposition is only possible at high temperatures. Thus mechanical activation was used in the present work for this purpose. After 90 minutes of mechanical activation, ...

Refractory linings can withstand severe working conditions and are widely used for the of many high temperature applications, such as steel ladles. Some these built with dry joints. These structures undergo very complex responses in service conditions, making prediction its behaviour a challenging task. To develop robust numerical tools, experimental validation is necessary. The present paper g...

Oceanic absorption of heat generated by greenhouse gas emissions has resulted in warming the dark ocean (>200 m) that contains a large refractory DOM (RDOM) pool. However, changes microbially mediated production and degradation dynamics for RDOM components response to marginal basins remain unclear. Herein, we integrated data from South China, Mediterranean Japan Seas (temperature range: 0.09–1...

The term biomining have been coined to refer to the use of microorganisms in mining processes as in the biooxidation of refractory gold minerals. The biooxidation of refractory gold ores presents similar characteristics when compared with roasting and pressure oxidation. Almost without exception, microbial extraction procedures are more environmentally friendly. The isolated bacteria in this st...