objective midazolam is a significant and effective drug for control of a life-threatening condition, generalized and partial refractory convulsive status epilepticus. the goal of this study was evaluation of midazolam efficacy for management of this serious disease and its two side effects, hypotension and respiratory failure. materials & methods our study was done using a quasi experimental me...

we discuss here an uncommon condition of neurogenic hypotension in the context of immunoglobulin light chain (amyloid light-chain) amyloidosis. th e most serious feature was autonomic nervous system impairment, mainly characterized by severe refractory orthostatic hypotension, which became progressively invalidating, forcing the patient to bed. moreover, since the systemic involvement of the di...

how to cite this article: fallah r, yadegari y, salmani nodushan m. efficacy and safety of intravenous sodium valproate in convulsive status epilepticus in children in shahid sadoughi hospital. iran. j. child. neurol 2012;6(2):39-44.   objective status epilepticus (se) is the most common pediatric neurologic emergency with high mortality and morbidity. there is no consensus on the drug of choic...

multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...

Aluminium phosphide (AlP) is used to kill rodents in grain storage. It produces phosphine gas which is toxic for mitochondria. The exact mechanism of action is unclear, but phosphine is thought to produce toxicity by blocking cytochrome-c oxidase, which inhibits oxidative phosphorylation and result in cell death. This poisoning has a high mortality, and survival is unlikely if more than 1.5 g i...

Infrared observations probe the warm gas in inner regions of planet-forming disks around young sun-like, T Tauri stars. In these systems, H$_2$O, OH, CO, CO$_2$, C$_2$H$_2$, and HCN have been widely observed. However, potentially abundant carbon carrier CH$_4$ remains largely unconstrained. The James Webb Space Telescope (JWST) will be able to characterize mid-infrared fluxes along with several...

BACKGROUND Children with Down syndrome (DS) have increased risk for developing AML (DS-AMKL), and they usually experience severe therapy-related toxicities compared to non DS-AMKL. Refractory/relapsed disease has very poor outcome, and patients would benefit from novel, less toxic, therapeutic strategies that overcome resistance. Relapse/resistance are linked to cancer stem cells with high alde...

Calcium aluminates (CA) are the most important hydraulically setting cements used for preparing refractory castables, because they develop high strength at very early ages after placements.  The anhydrous phases of this kind of cements are CA, CA2 and traces of C12A7 and alpha-alumina. The major hydraulic phase in all of the CA cements including ciment fondu...

Background Myeloproliferative disorders are a group of diseases characterized by increased proliferation of myeloid lineage. In addition to JAK2V617F mutation, several mutations in the c-MPL gene were described in patients with Philadelphia-negative chronic myeloproliferative disorders that could be important in the pathogenesis of diseases. The aim of present study was to investigate the fre...

Abstract This study reports the structure and mechanical properties of new refractory Ti 37.5 Nb 12.5 Hf 25 Al , 40 30 15 20 Ta 10 (at.%) high entropy alloys. After annealing at 1200 °C for 24 h, program alloys had a single-phase B2 structure. Further 600 h resulted in formation Widmanstatten orthorhombic particles (O-phase) bcc matrix. The annealed T = showed moderate strength good ductility (...