A novel antiherpetic agent, fattiviracin A1, was isolated from the culture broth of strain No. 2445 identified as Streptomyces microflavus. It was purified through 1-butanol extraction, column chromatographies on Diaion HP-10 and silica gel and HPLC using a reverse phase column. The structure of fattiviracin A1 was determined by several spectroscopic experiments and chemical degradations. It is...

Kamu borçlarında meydana gelen artışlar, büyüme, bütçe açığı, enflasyon gibi pek çok ekonomik değişken üzerinde olumsuz etkilere yol açabilmektedir. Özellikle ortaya çıkan belirsizliklerle birlikte borçlanmanın çıkaracağı artan maliyet, faiz oranlarının yükselmesine açmaktadır. Öte yandan oranları yatırım oranlarını azaltarak büyüme azalmasına Bu nedenle kamu borcu, uzun dönem kanalıyla ülkeler...

Six analogues of teh 33-residue shark repellent neurotoxin pardaxin were synthesized by the solid phase method: [Ala13]pardaxin, [Gly14,Gly15]pardaxin, des[1----9]pardaxin, [N1-succinamido]pardaxin, C33-dihydroxyethylamido]pardaxin, and C33-[diaminoethylamido]pardaxin. The spectroscopic and functional characterizations of the analogues are described. The peptides were characterized spectroscopi...

We attempted to separate species of the genus Clusia according to the concentration of linear alkanes (C25 and C35), and the presence and diversity of terpenes in epicuticular wax extracts. We collected leaves of 15 Clusia species growing in mountain forests of Panama (Cerro Jefe 1007 m and Altos de Campana 800 m a.s.l.) and from cultivated plants at two lowland sites. Leaf surfaces were washed...

Genetic mechanisms involved in prostate tumor progression from the androgen-responsive to androgen-unresponsive stage are not well understood because of the tremendous heterogeneity in the tumor as well as the lack of suitable models. Using 165 repeat microsatellite DNA markers distributed equally over all of the chromosomes, we determined an association between genetic alterations and androgen...

Chemistry of Dufour glands associated with the venom complex in Bracon cephi (Gahan) and Bracon lissogaster Muesebeck (Hymenoptera; Braconidae), two parasitoids of the wheat stem sawfly, Cephus cinctus Norton (Hymenoptera: Cephidae), was examined by solid phase micro-extraction (SPME) and gas chromatography/mass spectrometry. Homologous series of five chemical classes were detected in individua...

In order to compare the impact of tobacco on cancer risk across different countries of the world, we abstracted the estimated adult (age 30 years and above) deaths attributable to tobacco for all-malignant neoplasm, trachea, bronchus and lung cancer, and all other malignant neoplasms from the WHO Global Report entitled, Mortality Attributable to Tobacco, which was recently published in 2012. In...

Radioiodine therapy, the most effective form of systemic radiotherapy available, is currently useful only for thyroid cancer because of the thyroid-specific expression of the human sodium iodide symporter (hNIS). Here, we explore the efficacy of a novel form of gene therapy using prostate-specific membrane antigen (PSMA) promoter-mediated hNIS gene transfer followed by radioiodine administratio...

abstract this study investigates casual relationship between co2 emission and gross domestic product per capita in five different country groups, using cross- country data for the period 1960-2007. to achieve the purpose, the co- integration test and error correction models are applied. results confirm casual relationships between the two variables. a unilateral relationship between gdp and co2...