Oysters from the north-west coast of Canada contain high levels of cadmium, a toxic metal, in amounts that exceed food safety guidelines for international markets. A first required step to determine the sources of cadmium is to identify possible spatial and temporal trends in the accumulation of cadmium by the oyster. To meet this objective, rather than sample wild and cultured oysters of unkno...

Chronic exposures to cadmium compounds are carcinogenic. It was hypothesized that the development of resistance to cadmium may drive carcinogenesis. This is achieved by selection of resistant cells in which the apoptotic response is significantly attenuated. The induction of cadmium resistance in rat lung epithelial cells (LEC) was used to explore the mechanisms of cadmium-induced adaptation an...

Cadmium exposure has been linked to human cancers, including stomach cancer. In this study, the effects of cadmium on urokinase-type plasminogen activator receptor (uPAR) expression in human gastric cancer cells and the underlying signal transduction pathways were investigated. Cadmium induced uPAR expression in a time- and concentration-dependent manner. Cadmium also induced uPAR promoter acti...

OBJECTIVES To study longitudinal biological monitoring data on urinary and blood cadmium collected in a small cohort of nine workers who had been brazing for several years with solders containing cadmium. METHODS Cadmium was measured by neutron activation analysis in livers and kidneys, and estimates of renal function were carried out in 1983 and 1995. During the intervening period exposure t...

This study was conducted to evaluate the effect of ginger supplementation on plasma gonadotropin and steroid hormones of rats exposed to oxidative stress. In a completely randomized design, 16 newly weaned rats were randomly allocated to four treatments. Treatments were as: control, ginger (500 mg/kg body weight), Cadmium at 2 mg/kg body weight and combination of Cadmium and ginger gavaged for ...

AIM The present investigation has been conducted to evaluate the hepatoprotective activity of Moringa oleifera against cadmium-induced toxicity in rats. MATERIALS AND METHODS For this study, 18 Wistar albino rats were taken. Control group, Group I rats were given cadmium chloride @ 200 ppm per kg and Group II rats were treated with M. oleifera extract @ 500 mg/kg along with cadmium chloride @...

Cadmium is a toxic heavy metal which can cause numerous alterations in cell functioning. Exposure to cadmium leads to generation of reactive oxygen species, disorders in membrane structure and functioning, inhibition of respiration, disturbances in ion homeostasis, perturbations in cell division, and initiation of apoptosis and necrosis. This heavy metal is considered a carcinogen by the Agency...

Little is known about the etiology of pancreatic cancer, which is an important cause of cancer mortality in developed countries. We hypothesize that exposure to cadmium is a cause of pancreatic cancer. Cadmium is a nonessential metal that is known to accumulate in the human pancreas. The major risk factors for pancreatic cancer (increasing age, cigarette smoking, residence in Louisiana, and occ...

Cadmium, an important environmental toxic agent has the kidney as its most important target organ. It is concentrated mainly in the renal cortex. Excessive renal accumulation of cadmium causes well defined morphological and ultrastructural pathological changes in the proximal tubules. Functional changes accompanying cadmium nephropathy include proteinuria, enzymuria, aminoaciduria, glycosuria, ...

Mining activities can increase the bioavailability of metals in aquatic and terrestrial ecosystems. Following over 100 years of copper mining in portions of Michigan's Upper Peninsula (UP) terrestrial ecosystems retain vast quantities of waste rock with traces of cadmium and large concentrations of copper. We compared liver cadmium and copper concentrations in ruffed grouse (Bonasa umbellus), a...