An 85-year-old woman with chronic renal insufficiency presented with appetite loss and abdominal fullness. Laboratory data showed serum creatinine levels of 5.46 mg/ dL, urea nitrogen 42 mg/dL, corrected calcium 15.3 mg/ dL, intact PTH parathyroid hormone 15.1 pg/mL (N 10– 65), calcitriol 63.4 pg/mL (N 20–60), PTH-related protein 5.5 pmol/L (N < 1.0), cortisol of 4.3 pg/mL (N 6.2–19.4), ACTH ad...

In rat skeletal muscle, calcitriol, the hormonal form of vitamin D3, rapidly stimulates the biphasic formation of diacylglycerol (DAG), the second phase being independent of phosphoinositide hydrolysis driven by phospholipase C. In this work we showed that the effect of calcitriol on the second phase of DAG formation was totally inhibited in the absence of extracellular Ca2+ and by the Ca2+-cha...

Objectives: This study aimed to investigate the efficacy of calcitriol on Ischemia-reperfusion Injury (IRI) and inflammatory biomarkers in patients with non-ST-segment elevation acute coronary syndromes (NSTEACS) undergoing elective Percutaneous Coronary Intervention (PCI). Methods: A total of 72 patients with NSTEACS were randomly divided into two groups: (1) the calcitriol-treated grou...

• Atlantic cod has two vitamin D receptors (Vdra and Vdrb) with similar tissue expression. None of the tested PAHs were able to modulate Vdr activation alone. Phenanthrene, fluorene, pyrene antagonized calcitriol-mediated Vdra. Chrysene benzo[a]pyrene potentiated both Vdrs. can potentially pathway in fish. Vitamin receptor (VDR) mediates biological function steroid hormone calcitriol, which is ...

Cytochrome P450 enzyme CYP3A4 is an important drug-metabolizing enzyme, and high levels of tumoral expression of CYP3A4 are linked to drug resistance. We investigated the function of vitamin D-regulated miR-627 in intratumoral CYP3A4 suppression and its role in enhancing the efficacy of chemotherapy. We found that miR-627 targets CYP3A4 and suppresses CYP3A4 expression in colon cancer cell line...

The "Dietary Approaches to Stop Hypertension" (DASH) diet, rich in fiber and low-fat dairy, effectively lowers blood pressure. DASH's effect on calcitriol and other markers of bone-mineral metabolism is unknown. This secondary analysis of the DASH trial aimed to determine the effect of dietary patterns on blood concentrations of calcitriol, parathyroid hormone (PTH), ionized calcium, and urinar...

The present study investigates the hematologic effect of Calcitriol on rats undergoing sleep deprivation. Male Wistar rats were treated with Calcitriol 120 ng/kg and subjected to sleep deprivation for four successive days. Twenty four hour after last injection, animals were sacrificed and blood was collected for haematological analysis. A four-day sleep restriction caused a decline in total whi...

background periodontium may be able to respond to injuries by regeneration via the function of stem cells. objectives this study sought to assess the differentiation of human periodontal ligament stem cells (pdlscs) into osteoblasts in standard osteogenic medium and in a medium supplemented with 1,25-dihydroxyvitamin d3 (calcitriol). materials and methods in this experimental study, pdlscs were...

STUDY OBJECTIVE The chronically critically ill (CCI) are a subgroup of critically ill patients who have survived an acute critical illness but remain profoundly debilitated and ventilator dependent. We have previously shown that CCI patients have a very high prevalence of bone hyperresorption. The objective of this present study was to determine the biochemical response of bone hyperresorption ...

BACKGROUND 1,25-Dihydroxyvitamin D3 (calcitriol) inhibits proliferation and stimulates differentiation of multiple cell types, including osteoblasts. Human (h) bone marrow stromal cells (MSCs) are a homogenous non-hematopoietic population of cells present in the bone marrow and exhibit a less differentiated osteoblastic phenotype. The IGF system, including IGFs-I, and -II and IGF binding protei...