The genomic action of calcitriol (1,25-dihydroxy-vitamin D3) is mediated through the interaction of the calcitriol receptor (VDR) with vitamin D response elements (VDREs). Although renal failure is associated with resistance to the action of calcitriol, the mechanism of this resistance is not well understood. Therefore, we used the electrophoretic mobility shift assay to compare the ability of ...

Calcitriol pulse therapy has markedly changed the management of secondary hyperparathyroidism in chronic dialysis patients. However, there are still many patients even resistant to this therapy. Our observation of parathyroid size by ultrasonography revealed that these patients usually have enlarged parathyroid glands larger than 0.5 cm3. Such large parathyroid glands are composed of nodular hy...

Previous studies have demonstrated that global cerebral ischemia (GCI) causes neurological deficits and neuronal cell apoptosis. Calcitriol, a biologically active metabolite of vitamin D, exerts its endocrinological influence via nuclear vitamin D receptor. It is being assessed as an emerging therapeutic strategy in models of various medical conditions, including acute brain injury. The purpose...

the present work compared the clinical efficacy of ropically applied vitamin d3 (cholecalciferol), i a, 25 dihydroxy vitamin d3 (cakitriol) with calcipotriol (dovonex} in the treatment of plaque psoriasis. a randomized, double - blind, left - right, vehicle controlled study to assess the therapeutic efficacy and safety of mice daily application of 1 pg/g and 5 fj.g1g chalecakiferol. 1 pglg calc...

OBJECTIVE Abdominal aortic aneurysm (AAA) is a vascular disorder characterized by chronic inflammation of the aortic wall. Low concentrations of vitamin D3 are associated with AAA development; however, the potential direct effect of vitamin D3 on AAA remains unknown. This study evaluates the effect of oral treatment with the vitamin D3 receptor (VDR) ligand, calcitriol, on dissecting AAA induce...

BACKGROUND Calcitriol is documented to cause significant increase in bone mass densitometry counteracting osteoporosis. Promising results of calcitriol supplementation in studies aiming space flight induced osteoporosis is little and the effect of this hormone on biomarkers of bone metabolism is not examined yet in space flight models of osteoporosis in rats. METHODS This was an interventiona...

PURPOSE To investigate the killing effect of photodynamic therapy (PDT) mediated by hematoporphyrin derivative (HPD) on human breast cancer MCF7 and MDA-MB-231 cells in vitro. METHODS MCF7 and MDA-MB-231 breast cancer cells cultured in vitro were incubated with calcitriol (concentration of 10-8M, 10-10 M, 10-12 M, 10-14 M, 10-16 M, 0 M) to determine a proper concentration. The cells were divi...

BACKGROUND Treatment with calcitriol or its analogue, alfacalcidol often leads to hypercalcaemia, hyperphosphataemia or both in patients which chronic renal failure and advanced secondary hyperparathyroidism. We tested three new vitamin D analogues (CB 1093, EB 1213, GS 1725) in an attempt to identify potentially non hypercalcaemic compounds, capable of decreasing plasma parathyroid hormone (PT...

Friedreich ataxia (FA) is a neurodegenerative disease caused by the deficiency of frataxin, mitochondrial protein. In primary cultures dorsal root ganglia neurons, we showed that frataxin depletion resulted in decreased levels calcium exchanger NCLX, neurite degeneration and apoptotic cell death. Here, describe frataxin-deficient neurons display low ferredoxin 1 (FDX1), Fe/S cluster-containing ...

Erratum After publication of the original article [1], it came to the authors’ attention that Fig. 8, associated with the wound healing assay to show the migration of the cells following scratch, inadvertently placed the same representative images in both experimental groups (TGFβ1 + calcitriol and TGF-β2 + calcitriol) at 0H and 48H to indicate two different treatment groups. The 0H and 48H tim...