Two stereoisomeric cardenolides, uscharin (1) and a new compound, 2'-epi-uscharin (2), were isolated from the latex of Calotropis gigantea (Asclepiadaceae). Their structures were fully elucidated based on their spectroscopic data, X-ray crystallographic data and chemical evidences. Both epimers (1 and 2) exhibited strong inhibitory effects on HIF-1 activity with different magnitudes. Compound 1...

Information about trace element composition in vegetation from tropical environments is scarce. Trace elements were evaluated on vegetation samples collected at the Atlantic Fleet Weapons Training Facilities (AFWTF) in Vieques, agricultural areas in Vieques and mainland Puerto Rico, and at the Guánica State Forest. Analyses were conducted using atomic absorption after dry-ashing of samples and ...

INTRODUCTION Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in late...

Calotropis procera, a plant of family Asclepiadaceae is of immense importance as multipurpose plant with medicinal as well as traditional uses. Latex of this plant has been used to cure disease like leprosy, syphilis, inflammation, cutaneous infections, and malarial fever and in many more. In vitro culture of this pharmacologically plant is required otherwise it leads the segregated loss of des...

Antioxidant activity of a selection of commonly occurring wild plants growing in Beni-Sueif governorate, Upper Egypt, has been tested. The plants selected are Tamarix nilotica, Ambrosia maritima, Zygophyllum coccenium, Conyza dioscoridis, Chenopodium ambrosioides, and Calotropis procera. The in vitro antioxidant assays used in this study were 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scaven...