The locus ceruleus is among the earliest affected brain regions in Parkinson’s disease (PD) showing Lewy body pathology and neuronal loss. To improve our understanding of the pathogenesis of PD, we performed the first proteomic analysis ever of post-mortem locus ceruleus tissue of six pathologically confirmed PD patients, and six ageand gendermatched non-neurological controls. In total 2495 pro...

We present a list of 34 neglected entries from star cluster catalogues located at relatively high galactic latitudes (|b| > 15) which appear to be candidate late stages of star cluster dynamical evolution. Although underpopulated with respect to usual open clusters, they still present a high number density contrast as compared to the galactic field. This was verified by means of (i) predicted m...

According to astrophysical and cosmological observations, about 20 percent of the total energy in the universe is contributed by dark matter, which, within present observational limits, only exhibits gravitational interaction. Meanwhile, the Standard Model of elementary particles don’t contain such weakly-interacting constituents. To solve this mystery several schemes extending the Standard Mod...

It is now widely accepted that most of mass–energy in the universe is unobserved except by its gravitational effects. Baryons make only about 4% of the total, with “dark matter” making up about 23% and the “dark energy” responsible for the accelerated expansion of the universe making up the remainder. We focus on the dark matter, which is the primary constituent of galaxies. We outline the obse...

Deduction modulo is an extension of first-order predicate logic where axioms are replaced by a congruence relation on propositions and where many theories, such as arithmetic, simple type theory and some variants of set theory, can be expressed. An important question in deduction modulo is to find a condition of the theories that have the strong normalization property. Dowek and Werner have giv...

Background: The cerebrospinal fluid (CSF) concentration of α-synuclein may reflect the aggregation of α-synuclein in brain tissue that neuropathologically characterizes PD. Although most studies in large cohorts report reduced CSF α-synuclein levels in PD, the available data to date are not consistent due to variation in group sizes, pre-analytical confounding factors and assay characteristics....

We investigate the possibility that Dark Matter could be made of scalar candidates and focus, in particular, on the unusual mass range between a few MeV’s and a few GeV’s. After showing why the Lee-Weinberg limit (which usually forbids a Dark Matter mass below a few GeV’s) does not necessarily apply in the case of scalar particles, we discuss how light candidates (mdm < O(GeV) ) can satisfy bot...

In this paper I add uncertainty about the total vote count to a “citizen candidate” model of representative democracy. I show that in a society with a large electorate, where the outcome of the election is uncertain and where winning candidates receive a large reward from holding office, there will be a two-candidate equilibrium and no equilibria with a single candidate. ∗This work has benefite...

Sexually transmitted diseases (STDs) are caused by organisms that infect the mucosal surfaces of the genitourinary tract. In spite of its public health importance, particular scientific problems have delayed the development of an STD vaccine, such as incomplete attenuation (human herpes simplex virus type 2), accentuated immunopathology (Chlamydia trachomatis), poor immunogenicity (Treponema pa...

Sections 3 and 4 present the two versions of the model, which make different The model has a continuum of voters with unit mass and two candidates, 1 and 2. ABSTRACT We consider the Hotelling–Downs model with n 3 office-seeking candidates and runoff voting. We show that Nash equilibria in pure strategies. Congyi Xiang discover inside connections to recommended job candidates, industry January 2...