IMPORTANCE Invasive candidiasis in premature infants causes death and neurodevelopmental impairment. Fluconazole prophylaxis reduces candidiasis, but its effect on mortality and the safety of fluconazole are unknown. OBJECTIVE To evaluate the efficacy and safety of fluconazole in preventing death or invasive candidiasis in extremely low-birth-weight infants. DESIGN, SETTING, AND PATIENTS Th...

Sir, Recently, De Giorgi V et al. published an interesting clinical picture titled ‘Hyperplastic oral candidiasis of the tongue’. I read this article with great interest and compliment the authors for their clinical report. However, I would like to highlight several important issues. We should analyze carefully when the authors state, ‘Clinically, it is nearly impossible to differentiate such l...

Sir, Recently, De Giorgi V et al. published an interesting clinical picture titled ‘Hyperplastic oral candidiasis of the tongue’. I read this article with great interest and compliment the authors for their clinical report. However, I would like to highlight several important issues. We should analyze carefully when the authors state, ‘Clinically, it is nearly impossible to differentiate such l...

the increasing incidence of systemic candidiasis, which parallels the use of invasive and immunosuppressive medical procedures, necessitates development of rapid and cost effective tests for diagnosis of systemic candidiasis. therefore in this study 85 mice were first immunosuppressed by cyclophosphamide and then infected by candida albicans ncpf 3153. other 85 mice were employed as control. th...

Oral candidiasis is a common opportunistic infection of the oral cavity caused by an overgrowth of Candida species, the commonest being Candida albicans. The incidence varies depending on age and certain predisposing factors. There are three broad groupings consisting of acute candidiasis, chronic candidiasis, and angular cheilitis. Risk factors include impaired salivary gland function, drugs, ...

We have previously shown that intraperitoneal vaccination with the recombinant N terminus of Als1p (rAls1p-N) modestly improves survival during murine disseminated candidiasis. We now report marked efficacy with subcutaneous rAls1p-N vaccination. Efficacy is retained in neutropenic and corticosteroid-treated mice. The rAls1p-N vaccine is a promising candidate for the prevention of invasive cand...

We demonstrated 2 different antibodies against Candida albicans in patients' sera, the detection rates were proportional to the severity of candidiasis. One antibody was directed toward antigen shared by Candida in both blastospore and mycelial phases and the other was directed against antigen found only in the mycelial phase of Candida. The presence of the latter may reflect the invasive form...