twenty-one patients with advanced breast cancer (7 premenopausal and 14 postmenopausal women) were treated with a combination of cyclophosphamide, doxorubicin, and cisplatin (cap). the median age of the patients was 43 years (range 36-61). this therapy was repeated every 3 weeks. nine patients (group 1) received cap as primary therapy for metastatic breast cancer, and twelve patients (group 2) ...

Background. Community acquired pneumonia (CAP) is a common serious infection that usually treated with macrolide β-lactam while doxycycline considered an alternative due to limited evidence. Hence, we aimed evaluate azithromycin versus containing regimen in achieving clinical stability for inpatients CAP. Materials and Methods. retrospective cohort of CAP receiving either or combined β-lactam. ...

The objective of this study was to determine if the current dosage regimen for chloramphenicol CAP administered to children with severe malaria SM for presumptive treatment of concomitant bacterial meningitis achieves steady state plasma CAP concentrations within the reported therapeutic range of 10-25 mg/l. Fifteen children (11 male, 4 female) with a median age of 45 months (range: 10-108 mont...

OBJECTIVE To date, no standard regimen for salvage chemotherapy after gemcitabine (Gem) failure has been defined for patients with advanced pancreatic cancer (PC). Oral capecitabine (Cap) has shown promising activity in first-line chemotherapy trials in PC patients. METHODS Within a prospective single-center study, Cap was offered to patients who had already received at least 1 previous treat...

• Objective: To evaluate the relationship between antimicrobial selection and length of hospital stay (LOS) in patients with community-acquired pneumonia (CAP). • Design: Retrospective, observational, multicenter study. • Setting and participants: 376 hospitalized inpatients with mild to moderately severe CAP treated in 9 U.S. hospitals between January 1999 and April 2000. • Measurements: Demog...

There is evidence to suggest that single-agent broad spectrum antibacterials may be cost-effective alternatives to combination antibiotics for the empirical management of febrile neutropenia in cancer patients. The objectives of the present study were 2-fold. The first objective was to compare the clinical effectiveness of ceftazidime monotherapy with that of 2 combination antibiotic regimens i...

Community acquired pneumonia (CAP) represents the most common cause of infection-related morbidity and mortality worldwide. Appropriate treatment of CAP is challenging and sometimes limited by the availability to obtain rapid and timely identification of the etiologic agent in order to initiate or deescalate the correct antimicrobial therapy. As a consequence, prescribers frequently select empi...

Sir—I read with interest the article by Johnson [1] suggesting a more prominent role for doxycycline in empiric therapy for community-acquired pneumonia (CAP). A response by Lederman et al. [2] described an in vitro susceptibility survey that compared tetracycline with doxycy-cline against bacterial pathogens causing CAP. The survey emphasized the relative lack of susceptibility of Streptococcu...

OBJECTIVE Current criteria for performing relaparotomy for suspected peritonitis are non explicit and based on non-quantitative, subjective arguments or hospital practice. The aim of this study was to determine the value of routinely used clinical and diagnostic parameters in early detection of postoperative, diffuse peritonitis (PP). Furthermore, the prognosis and outcome after early indicatio...

Community acquired pneumonia (CAP) is a common medical problem. Over 1.5 million patients annually will be diagnosed with CAP and treated with empiric therapy initially. The vast majority of patients will improve with a single course broad spectrum antimicrobial agent. Rarely a patient will not improve and some may progress on this regimen. Giving a second course of broad spectrum antimicrobial...