background: current who best infection control practices for injections do not address the use of hub cutters due to insufficient evidence on safety and efficacy. objective: to assess the impact of the use of hub cutters on 1) the frequency of needle-stick injuries (nsis) and other blood exposures among workers and 2) the volume of sharps waste in a mass vaccination campaign setting. methods: d...

Facility-location problems have several applications in telecommunications, industrial transportation and distribution, etc. One of the most well-known facility-location problems is the p-median problem. This work addresses an application of the capacitated p-median problem to a real-world problem. We propose a genetic algorithm (GA) to solve the capacitated pmedian problem. The proposed GA use...

Hervé Abdi, Vincent Guillemot, Aida Eslami and Derek Beaton School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, USA Bioinformatics and Biostatistics Hub, Institut Pasteur (IP), C3BI, USR 3756 CNRS, Paris, France Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada Rotman Research Institute, Baycrest Health Sciences, Toro...

The problem of finding a Capacitated Minimum Spanning Tree asks for connecting a set of client nodes to a root node through a minimum cost tree network, subject to capacity constraints on all links. This paper reports on our design, implementation and performance evaluation of a hybrid Ant Colony Optimization algorithm for finding Capacitated Minimum Spanning Trees. Our Ant Colony Optimization ...

Recently, Chakrabarty et al. [5] initiated a systematic study of capacitated set cover problems, and considered the question of how their approximability relates to that of the uncapacitated problem on the same underlying set system. Here, we investigate this connection further and give several results, both positive and negative. In particular, we show that if the underlying set system satisfi...

In the facility location problem usually reducing total transferring cost and time are common objectives. Designing of a network with hub facilities can improve network efficiency. In this study a new model is presented for P-hub covering location problem. In the p-hub covering problem it is attempted to locate hubs and allocate customers to established hubs while allocated nodes to hubs are in...

We develop a simple and practical exact algorithm for the problem of locating p facilities and assigning clients to them within capacity restrictions in order to minimize the maximum distance between a client and the facility to which it is assigned (capacitated p-center). The algorithm iteratively sets a maximum distance value within which it tries to assign all clients, and thus solves bin-pa...

1Institut Pasteur – Bioinformatics and Biostatistics Hub – C3BI, USR 3756 IP CNRS – Paris, France 2Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK 3European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Trust Genome Campus, Cambridge, UK 4Oncology Innovative Medicines and early Development, AstraZeneca, Cambridge, UK 5RWTH Aach...