Lipase catalysis in nonaqueous media is recognized as a powerful tool in organic and more recently polymer synthesis. Even though none of the currently known polyhydroxyalkanoate (PHA) depolymerases have lipase activity, they do have a catalytic center that resembles that of lipases. Motivated by the above, the potential of using the poly(3-hydroxybutyrate), PHB, depolymerase from Psuedomonas l...

Libraries of lanthanide complexes supported by nitrogen and oxygen containing ligands have been synthesised using a high-throughput approach. The complexes were employed in the ring-opening polymerisation of epsilon-caprolactone, in some cases giving polycaprolactone of controlled molecular weight and narrow polydispersity. The libraries, based on twenty-one ligands and eight lanthanide reagent...

The identity of the c-caprolactone products from polymerization under the influence of amines has been studied, and conclusion about alkyl oxygen fission of the lactone ring at polymerization has been made. The main kinetic features of polymerization and molecular-weight distribution change on forming poly-C-caprolactone are discussed. On the basis of these data, polymerization mechanisms for l...

In this study, we fabricated nano-sized calcium silicate/poly(epsilon-caprolactone) composite (n-CPC) and micro-sized calcium silicate/poly(epsilon-caprolactone) composite (m-CPC). The composition, mechanical properties, hydrophilicity and degradability of both n-CPC and m-CPC were determined, and in vitro bioactivity was evaluated by investigating apatite forming on their surfaces in simulated...

Reaction of the OOO-coordinating tridentate bis(phenolate) protio-ligand 2,2'-{oxybis(methylene)}bis{4,6-di(1-methyl-1-phenylethyl)phenol} (L(O3)-H2), with 1 equiv. of KN(SiMe3)2 in toluene or THF yielded [K(L(O3)-H)] (1) or [K(L(O3)-H)(THF)] (2), respectively. Single-crystal X-ray diffraction studies of 1 and 2 revealed mononuclear structures with the phenyl rings of the bulky ligand displayin...

This study was aimed at developing a polymeric drug delivery system for a steroidal aromatase inhibitor, exemestane (exe) intended for sustained targeted delivery of drug through intravenous route. Carboxylated polycaprolactone (cPCL) was synthesized by ring opening polymerization of caprolactone. Exe-loaded cPCL nanoparticles (NPs) were prepared by interfacial deposition of preformed polymer a...

0014-3057/$ see front matter 2008 Elsevier Ltd doi:10.1016/j.eurpolymj.2008.08.029 * Corresponding author. Tel.: +4687908118; fax: E-mail address: [email protected] (L.A. Berglund). A technical problem in cellulosic nanocomposite materials is the weak interaction between hydrophilic cellulose and hydrophobic polymer matrices. One approach to solve this difficulty is to chemically graft monomers of t...

Abstract The synthesis of poly(ε-caprolactone) (PCL) tetra-arm star polymer was carried out using “click” chemistry and ring-opening polymerization techniques. For this purpose, azido (PCL-N 3 ) acquired ε-caprolactone 2-[2-(2-azidoethoxy)ethoxy]ethanol (N ol). N ol obtained sodium azide 2-[2-(2-chloroethoxy)ethoxy]ethanol. 4-(prop-2-ynyloxy)-phthalonitrile by 4-nitrophthalonitrile propargyl al...

regeneration and engineering of functional new tissues containing the neural network have great importance. progression of neural network into the dental tissue has a crucial role in dental tissue regeneration. in the present study polymer-ceramic blended scaffolds containing different weight percentages of carbon nanotube in poly caprolactone nanofiber matrix were fabricated. morphological, me...

In this paper, ibuprofen was encapsulated into microspheres by oil-in-water (o/w) emulsion solvent evaporation method. Biodegradable polymers with certain compositions and characteristics such as polylactide (PLA), poly(epsilon-caprolactone) (PCL) and their block copolymer were used to prepare the microspheres. The results indicate that, under the same processing conditions, the drug entrapment...