Patients' sera were analyzed for carbamazepine and ethosuximide by enzyme immunoassay (x) and gas chromatography (y), and the results were compared. The correlation coefficients were: for carbamazepine, x vs. y 0.94 (n = 93); for ethosuximide, x vs. y 0.99 (n = 30). These results suggest that the two methods could be used interchangeably. Ten serum samples supplemented with carbamazepine (2.5 t...

Monitoring of plasma antiepileptic drugs is useful for better clinical management in epileptic patients, particularly in children. Carbamazepine (CBZ) is one of the commonly prescribed anticonvulsants. The active metabolite of carbamazepine-carbamazepine-10-11 epoxide (CBZ-Epo) also exhibits anticonvulsant effect. The pineal hormone, melatonin exerts an anticonvulsant effect in experimental sei...

leviteracetam (lev) is a novel antiepileptic drug with improved tolerance and safety, while carbamazepine (cbz) represents classical antiepileptic drugs. so far, a systemic comparison of the efficacy and side effects of these two drugs is lacking. a literature review on the comparison of leviteracetam versus carbamazepine for patients with epilepsy was performed up to september 2013 using pubme...

Carbamazepine and amiodarone may often be used together, especially in countries where cardiomyopathies are common. In this study single doses of carbamazepine (400 mg) were given to patients with cardiac disease before and after one month of therapy with amiodarone, 400 mg daily. The kinetic profile of carbamazepine, its free fraction, and serum amiodarone, were measured at the two occasions. ...

OBJECTIVE To identify specific major congenital malformations associated with use of carbamazepine in the first trimester of pregnancy. DESIGN A review of all published cohort studies to identify key indications and a population based case-control study to test these indications. SETTING Review of PubMed, Web of Science, and Embase for papers about carbamazepine exposure in the first trimes...

carbamazepine are very similar to the clinical features of water intoxication. Dizziness, headaches, nausea, and mental confusion may occur with both, although it is not known what proportion of patients who develop these side effects on carbamazepine do so because of a fall in the plasma osmolality. When untoward symptoms develop during treatment and subside after the dose is reduced the mecha...

PURPOSE Evaluate the efficacy of carbamazepine in the treatment of idiopathic generalized epilepsy (IGE). METHOD The response of five patients with IGE, who experienced primarily generalized tonic-clonic seizures which were refractory to multiple antiepileptic drugs, is reported. RESULTS Carbamazepine controlled multiple seizure types and did not induce or increase the frequency of myocloni...

We report a case of carbamazepine withdrawal syndrome following in utero exposure to carbamazepine related to a pharmacogenetic predisposition factor. The infant was born at 37 1/7 weeks' gestation by cesarean section to a mother treated for epilepsy with carbamazepine. One hour and thirty minutes after birth, the infant presented a respiratory distress with severe oxygen desaturation requiring...