The risk of hypoglycemia is a major barrier to intensifying medical therapy in patients with diabetes who use insulin secretagogues or exogenous insulin.1–3 By promoting the transport of blood glucose into insulin-sensitive tissues, these medications can cause hypoglycemia if their action is not counterbalanced by carbohydrate intake. Conversely, excessive carbohydrate intake can override the e...

Novel composites between cellulose (CEL) and keratin (KER) from three different sources (wool, hair and chicken feather) were successfully synthesized in a simple one-step process in which butylmethylimidazolium chloride (BMIm+Cl−), an ionic liquid, was used as the sole solvent. The method is green and recyclable because [BMIm+Cl−] used was recovered for reuse. Spectroscopy (FTIR, XRD) and imag...

Abstract Ion channels play key roles in regulating the ion environment inside and outside cell. Sialylated glycans (SGs) at terminus of voltage-gated (VGICs) are abundant directly control switch VGICs, while SGs on cell surface also closely related to virus infection, tumor growth, metastasis. Here, we report a biomimetic nanochannel device that can be precisely regulated by SG. The is composed...

Rumen microbes produce cellular protein inefficiently partly because they do not direct all ATP toward growth. They direct some ATP toward maintenance functions, as long-recognized, but they also direct ATP toward reserve carbohydrate synthesis and energy spilling (futile cycles that dissipate heat). Rumen microbes expend ATP by vacillating between (1) accumulation of reserve carbohydrate after...

Sports Nutrition Evolution The importance of carbohydrate for athletes was recognized as far back as the 1924 Boston marathon where it was discovered that blood glucose levels decreased in the top runners during the 1924 Boston marathon. The following year carbohydrate feeding was shown to prevent the decline in blood glucose and improve performance. However the notion that carbohydrate feeding...

G lucose is central to all of metabolism. It is the universal fuel for human cells and the source of carbon for the synthesis of most other compounds. Every human cell type uses glucose to obtain energy. The release of insulin and glucagon by the pancreas aids in the body’s use and storage of glucose. Other dietary sugars (mainly fructose and galactose) are converted to glucose or to intermedia...