The influence of cholestyramine and chenodeoxycholic acid on the induction of liver cirrhosis by carbon tetrachloride was investigated in the Wistar rat. The addition of 1.3% cholestyramine to the diet of the experimental animals inhibited to a large extent the induction of cirrhosis. While all the animals subjected to carbon tetrachloride exposure plus basal diet and those to carbon tetrachlor...

for a number of experiments on the toxicity of carbon tetrachloride under various conditions of diet, etc. In all we have given carbon tetrachloride to 87 cats, in various dosages and under various dietary conditions and have found the susceptibility of cats to this drug so great that it was impossible to get more than suggestive results from our various experiments. Ninety-two per cent, of the...

The expression of mitochondrial voltage-dependent anion channels (VDAC) may underlie the protective effects of Limonium sinense (Girard) Ktze root extracts (LSE) against carbon tetrachloride-induced liver damage. Pretreatment of mice with 100 mg/kg, 200 mg/kg or 400 mg/kg LSE significantly blocked the carbon tetrachloride-induced increase in both serum aspartate aminotransferase (sAST) and seru...

CONTEXT Cirrhosis is a progressive chronic hepatopathy which constitutes an irreversible stage of liver dysfunction. OBJECTIVES To evaluate the oxidative stress in the blood of cirrhotic rats treated with the antioxidant melatonin. METHODS Cirrhosis was induced through inhalation of carbon tetrachloride. Liver integrity was evaluated by measuring serum enzymes, oxidative damage measured by ...

1. The actions of various inhibitors of the microsomal NADPH-cytochrome P-450 electron-transport chain have been studied on the stimulatory effect of carbon tetrachloride on malonaldehyde production. 2. Carbon monoxide, p-chloromercuribenzoate, beta-diethylaminoethyl-3,3'-diphenylpropyl acetate (SKF 525A) and nicotinamide did not decrease the stimulatory action of carbon tetrachloride on malona...

The thermal decomposition of carbon tetrachloride on clean iron was studied in ultrahigh vacuum using molecular beam strategies, where it is found that carbon tetrachloride thermally decomposes on the surface to deposit iron and carbon with exactly identical kinetics as found at high pressures. No gas-phase products are detected and the activation energy for the reaction (14.2 ± 0.5 kcal/mol) i...

The potential of aqueous extract of the leaves of Acalypha wilkesiana, to protect against carbon tetrachloride induced liver damage was investigated in Wistar albino rats. The carbon tetrachloride was prepared 1:5 (v:v) in olive oil, and administered subcutaneously at 1 mL/kg body weight. The extract was administered to both normal and carbon tetrachloride treated rats at 100, 200 and 300 mg/kg...

The ability of an aqueous extract of the rhizomes of Sansevieria liberica to protect against carbon tetrachloride induced liver injury was investigated in Wistar albino rats. The carbon tetrachloride was prepared 1:5 (v:v) in olive oil, and administered subcutaneously at 1 mL/kg body weight. The extract was administered to both normal and carbon tetrachloride treated rats at 100, 200 and 300 mg...

an experiment was conducted to study the effects of carbon tetrachloride (ccl4) on post-peak performance and serum enzymes of hy-line w-36 laying hens from 32-36 weeks of age. the experiment was carried out with a total of 192 laying hens in a completely randomized block design. during the experiment laying hens were allocated to 4 groups consisted of t1) no ccl4 as control diet, t2, t3 and t4)...

background: tissue protective effect of compounds with antioxidant properties has been demonstrated. the alkaloids found in barberry root are considered as antioxidants. objective: according to barberry protective effects in different tissues, in this study, the protective effect of berberis integerrima bge. root )mebir) was evaluated against ccl4-induced testicular damages in wistar rats. mate...