Eph receptor (Eph)-ephrin signaling plays an important role in organ development and tissue regeneration. Bidirectional signaling of EphB4-ephrinB2 regulates cardiovascular development. To assess the role of EphB4-ephrinB2 signaling in cardiac lineage development, we utilized two GFP reporter systems in embryonic stem (ES) cells, in which the GFP transgenes were expressed in Nkx2.5(+) cardiac p...

Introduction: One of the important tasks of nurses in intensivecare unit is interpretation of ECG. The use of training simulator isa new paradigm in the age of computers. This study was performedto evaluate the impact of cardiac arrhythmias simulator softwareon nurses’ learning in the subspecialty Vali-Asr Hospital in 2016.Methods: This study was conducted by quasi-experimentalrandomized Salomo...

The heart consists of many types of cells, including cardiomyocytes, vascular cells, neural cells, and cardiac fibroblasts. Adult cardiomyocytes are terminally differentiated cells, and loss of cardiomyocytes as a result of heart damage is irreversible. To regenerate damaged hearts and restore cardiac function, understanding the cellular and molecular basis of heart development is of considerab...

granulocytic sarcomas (chloromas) are rare extramedullary tumors consisting of primitive granulocytic cells. we report here on a case of a 23-year-old man who presented with a generalized swelling. he is known case of acute myelomonocytic leukemia. granulocytic sarcomas are rare, destructive, extramedullary tumor masses that consist of immature granulocytic cells. in this unusual patient's case...

Conrad Waddington's famous illustration of a ball poised at the top an undulating epigenetic landscape is often evoked when one thinks epigenetics. Although original figure was metaphor for gene regulation during cell fate determination, we now know that important homeostasis every tissue and organ in body. This evident cardiovascular system, first organs to develop whose function vital human l...

MicroRNAs (miRNAs) are a class of endogenous small noncoding RNAs that regulate gene expression either by degrading target mRNAs or by suppressing protein translation. miRNAs have been found to be involved in many biological processes, such as development, differentiation, and growth. However, the evolution of miRNA regulatory functions and networks has not been well studied. In this study, we ...

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