BACKGROUND Carboxyl terminus of Hsp70-interacting protein (CHIP) is a chaperone/ubiquitin ligase that plays an important role in stress-induced apoptosis. However, the effect of CHIP on angiogenesis, cardiac function and survival 4 weeks after myocardial infarction (MI) remain to be explored. METHODS Wild-type (WT) and transgenic mice (TG) with cardiac-specific overexpression of CHIP were use...

Hypertensive patients with large blood pressure variability (BPV) have aggravated end-organ damage. However, the pathogenesis remains unknown. We investigated whether exaggerated BPV aggravates hypertensive cardiac remodeling and function by activating inflammation and angiotensin II-mediated mechanisms. A model of exaggerated BPV superimposed on chronic hypertension was created by performing b...

Background—Constrictive pericarditis represents a serious hemodynamic syndrome that may lead to heart failure. Studies of its pathophysiological mechanisms have been impeded by the lack of an animal model. Methods and Results—Cardiac myosin–induced experimental autoimmune myocarditis in interferon (IFN)– knockout (KO) mice results in increased cardiac inflammation and development of severe gros...

Inflammation has been recognized increasingly as a critical pathologic component of a number of heart diseases. A mouse model of autoimmune myocarditis was developed to study the role of immune mediators in the development of cardiac dysfunction. We have found previously that IFN-gamma deficiency promotes inflammation in murine myocarditis. It has been unclear, however, how IFN-gamma deficiency...

t-wave oversensing occurs when the counter starts giving dual beeps for every cardiac cycle instead of one. this usually happens when the monitoring lead displays a tall t wave, which is also sharp. r wave sensing algorithms of the devices do not sense t wave because the slow rate of the t wave is much less than that of the r wave. but the slow rate of t waves may change with time and also beca...

Stress cardiomyopathy (SC) is an increasingly recognized form of acute heart failure, which has been linked to a wide variety emotional and physical triggers. The pathophysiological mechanisms the disease remain incompletely understood, however, inflammation recently shown play pivotal role. This review summarizes most notable findings myocardial inflammation, demonstrated from biopsies cardiac...