In this study, we examined cardiac inflammation, fibrosis and left ventricular (LV) function during the development of streptozotocin (STZ)-induced diabetic cardiomyopathy using an animal model of diabetes mellitus (DM). Diabetes was induced in 22 Sprague‑Dawley rats by an intraperitoneal single injection of STZ (70 mg/kg). Non-diabetic animals served as the controls (n=6). LV function was docu...

A20 or tumor necrosis factor-induced protein 3 is a negative regulator of nuclear factor kappaB signaling. A20 has been shown previously to attenuate cardiac hypertrophy in vitro and postmyocardial infarction remodeling in vivo. In the present study, we tested the hypothesis that overexpression of A20 in the murine heart would protect against cardiac hypertrophy in vivo. The effects of constitu...

A20 or tumor necrosis factor–induced protein 3 is a negative regulator of nuclear factor B signaling. A20 has been shown previously to attenuate cardiac hypertrophy in vitro and postmyocardial infarction remodeling in vivo. In the present study, we tested the hypothesis that overexpression of A20 in the murine heart would protect against cardiac hypertrophy in vivo. The effects of constitutive ...

chronic obstructive pulmonary disease (copd) is a condition associated with inflammation in lungs and airways. the impacts of inflammatory process is not limited to respiratory system but extend to extrapulmonary organs with resultant complications involving endocrine, metabolic and cardiovascular systems. the extent and severity of inflammation may be partly estimated by serum measurement of s...

Salusin-β accelerates inflammatory responses in vascular endothelial cells, and increases oxidative stress in vascular smooth muscle cells. Plasma salusin-β levels were increased in diabetic patients. This study was designed to determine whether salusin-β is involved in the pathogenesis of diabetic cardiomyopathy (DCM), and whether knockdown of salusin-β attenuates cardiac inflammation and oxid...

PURPOSE OF REVIEW With the intention to summarize the currently available evidence on the pathophysiological relevance of inflammation in heart failure, this review addresses the question whether inflammation is a cause or consequence of heart failure, or both. RECENT FINDINGS This review discusses the diversity (sterile, para-inflammation, chronic inflammation) and sources of inflammation an...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a type of human that resulted in the 2019 disease (COVID-19). Although it was generally categorized as disease, its involvement cardiovascular complications identified from onset. Elevated cardiac troponin levels (a myocardial injury marker) and echocardiograms, which showed anomalous performance patients’ hearts, were noted early ...

Aim: Cisplatin (CP) is used to treat a variety of cancers as chemotherapeutic agent. This drug has also severe side effects and its use exhibits serious toxicity in number organs, including kidney heart. The aim the present study was evaluate ultrastructural inflammatory changes induced by CP treatment rat cardiac tissue time-dependent manner.
 Material Methods: Rats were randomly divided ...

Cardiovascular diseases remain one of the major health problems worldwide. The worldwide research against cardio-vascular diseases as well as genome wide association studies were successful in indentifying the loci associated with these prominent life threatening diseases but still a substantial amount of casualty remains unexplained. Over the last decade, the thorough understanding of molecula...

Cardiotoxicity, which may result from intense cardiac oxidative stress and inflammation, is the main limiting factor of the anticancer therapy using doxorubicin. Because statins might exert beneficial pleiotropic cardiovascular effects, among other things, by anti-inflammatory and antioxidative mechanisms, we investigated whether or not fluvastatin pretreatment can attenuate doxorubicin-induced...