objective(s): this study investigated the protective effect of tanshinone iia sodium sulfonate (tss) on ischemia-reperfusion (i/r) induced cardiac injury, and the underlying mechanism of action. materials and methods:male sprague-dawley rats were subjected to a 30-min coronary arterial occlusion followed by 24 hours' reperfusion. half an hour before the left coronary artery ligation, rats ...

background: despite the emerging evidence on beneficial effects of probiotics on the cardiovascular system, their impact on the management of ischemic heart diseases and its possible mechanism have not been elucidated. methods: four viable probiotics bacterial strains, including bifidobacterium breve, lactobacillus casei, lactobacillus bulgaricus and lactobacillus acidophilus, at the concentrat...

The most common causes of severe head injuries are motor vehicle accidents and falls from a height that cause cardiac arrest. Cardiac arrest resulted in the patient being unconscious, no breathing, pulse. incidence is mostly because hypoxic. Patients with characterized by Gasglow Coma Scale (GCS) 8 or less. who often have decreased oxygen saturation should require definitive airway to prevent d...

Wnts are required for cardiogenesis but the role of specific Wnts in cardiac repair remains unknown. In this report, we show that a dynamic Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair. Acute ischaemic cardiac injury upregulates Wnt1 that is initially expressed in the epicardium and subsequently by cardiac fibroblasts in the region of ...

Recent studies have revealed the critical role of microRNAs (miRNAs) in regulating cardiac injury. Among them, the cardiac enriched microRNA-1(miR-1) has been extensively investigated and proven to be detrimental to cardiac myocytes. However, solid in vivo evidence for the role of miR-1 in cardiac injury is still missing and the potential therapeutic advantages of systemic knockdown of miR-1 ex...

Background: Acute kidney injury (AKI) is a common complication associated with cardiac surgery cardiopulmonary bypass (CPB) deleterious effect on morbidity and mortality. The current st...

Background and Aims: Ecstasy or 3, 4-methylenedioxymethamphetamine (MDMA) is a brain stimulant and a hallucinogenic material prepared by chemical changes in amphetamine. The aim of this study was to evaluate the changes induced by this drug in mouse cardiac histopathology, electrocardiogram (ECG) and blood cell counts. Materials and Methods: In this experiment, 3 groups (n=10) of mice were e...