Background—Recent studies suggest that mutations in cardiac mitochondrial DNA (mtDNA) may contribute to the development of dilated cardiomyopathy. The mechanisms that regulate those mutations, however, remain undefined. Thus, we studied cardiac mtDNA repair mechanisms, mtDNA damage, and mitochondrial structure and function in mice with heart failure secondary to overexpression of TNF(TNF1.6 mic...

BACKGROUND Mitral valve repair is considered better than mitral valve replacement for degenerative mitral regurgitation. AIM To evaluate late clinical results of mitral valve repair as compared to mitral valve replacement in patients with degenerative mitral regurgitation. PATIENTS AND METHODS All patients subjected to open heart surgery for degenerative mitral regurgitation between 1990 an...

TECHNIQUE For patients arriving in cardiopulmonary arrest, emergency department thoracotomy is indicated. For those patients arriving stable enough to be transported to the operating room, median sternotomy is the incision of choice. Penetrating injuries to the heart will inevitably cause bleeding of the myocardium, mandating repair to prevent cardiac tamponade. Suture repair of a cardiac lacer...

TECHNIQUE For patients arriving in cardiopulmonary arrest, emergency department thoracotomy is indicated. For those patients arriving stable enough to be transported to the operating room, median sternotomy is the incision of choice. Penetrating injuries to the heart will inevitably cause bleeding of the myocardium, mandating repair to prevent cardiac tamponade. Suture repair of a cardiac lacer...

This article reviews the current progress and research indications in the application of natural plant compounds with the potential for the treatment of cardiovascular diseases. Our understanding of how to apply natural plant compounds to enhance mechanisms of inherited cardiac regeneration, which is physiologically pertinent to myocyte turnover or minor cardiac repair, for substantial cardiac ...

Anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) is a rare congenital cardiac malformation. We report three cases of ALCAPA who survived to adulthood. The first case was a 51-year-old woman who complained of typical chest pain that was diagnosed with ALCAPA using cardiac catheterization and coronary computed tomographic angiography (CTA). The second case was a 30-...

anomalous origin of the left coronary artery from the pulmonary artery (alcapa) is a rare congenital cardiac malformation. we report three cases of alcapa who survived to adulthood. the first case was a 51-year-old woman who complained of typical chest pain that was diagnosed with alcapa using cardiac catheterization and coronary computed tomographic angiography (cta). the second case was a 30-...

Despite increasing trends in catheter-based cardiac surgical procedures, more than 278 000 Americans had traditional cardiac surgery in 2013. Of those surgical procedures, approximately 133 000 involved valvular repair or replacement. Aortic valve replacement was by far the most common valvular operation, followed by mitral valve repair or replacement. This review article will discuss character...

In the last two decades, morbidity and mortality of patients with chronic heart failure could be further reduced by improved pharmacological and cardiac device therapies. However, despite these advances, there is a substantial unmet need for novel therapies, ideally specifically addressing repair and regeneration of the damaged or lost myocardium and its vasculature, given the limited endogenou...