Clinical studies demonstrate benefits of exercise in both preventing cardiovascular disease in the general population and mitigating existing disease in cardiovascular patients.1–3 Systemic effects of exercise on skeletal muscle and peripheral vessels as well as metabolism and insulin sensitivity undoubtedly contribute to these benefits. However, growing evidence from animal studies suggests th...

Ginsenoside Rg3 (Rg3) is a rare type of ginsenoside used as an anti-tumor medicine in China. Ginsenoside Rb1 (Rb1), which exhibits protective effects on the cardiovascular system, is similar to Rg3 in chemical structure. In the present study, Rb1 and Rg3 were administered for 6 weeks to spontaneously hypertensive rats (SHR) and their cardioprotective effects were assessed. According to echocard...

Cardiovascular diseases are widespread throughout the world. The incidence of cardiovascular system has increased several times. have become leading cause death in many countries. Currently, efforts researchers aimed at studying and creating new, more effective safe drugs their combinations for treatment pathology system. Candesartan cilexetil is an angiotensin II receptor antagonist. It used m...

Increased levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) in plasma is associated with a reduced risk developing cardiovascular diseases (CVD). In addition to its potential cardioprotective function, HDL ApoA1, the main apolipoprotein, also have antidiabetic properties. The aim study was determine level ApoA1 blood patients (n = 81) type 2 diabetes mellitus ...

Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury, neither the specific PDE3 isoform involved nor the underlying mechanisms have been identified. Targeted disruption of PDE3 subfamily B (PDE3B), but not of PDE3 subfamily A (PDE3A), protected mouse heart from I/R injury in vivo and in vitro...

Exercise increases serum opioid levels and improves cardiovascular health. Here we tested the hypothesis that opioids contribute to the acute cardioprotective effects of exercise using a rat model of exercise-induced cardioprotection. For the standard protocol, rats were randomized to 4 days of treadmill training and 1 day of vigorous exercise (day 5), or to a sham exercise control group. On da...

Cardiovascular disease is the leading cause of mortality in type 2 diabetes mellitus. Hyperinsulinemia is associated with increased cardiovascular risk, but the effects of exogenous insulin on cardiovascular disease progression have been less well studied. Insulin has been shown to have both cardioprotective and atherosclerosis-promoting effects in laboratory animal studies. Long-term clinical ...

BACKGROUND Randomized clinical trials showed the benefit of pharmacological and revascularization treatments in secondary prevention of myocardial infarction (MI), in selected population with highly controlled interventions. The objective of this study is to measure these treatments' impact on the cardiovascular (CV) mortality rate among patients receiving usual care in the province of Quebec. ...