Ischemic heart disease including myocardial infarction develops on the basis of several risk-factors and comorbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of novel drug targets for cardioprotection is of great importance. Ischemic preconditioning, postconditioning, and re...

Modulation of posttranslational modifications (PTMs), such as protein acetylation, is considered a novel therapeutic strategy to combat the development and progression of cardiovascular diseases. Protein hyperacetylation is associated with the development of numerous cardiovascular diseases, including atherosclerosis, hypertension, cardiac hypertrophy, and heart failure. In addition, decreased ...

Ischemic heart disease including myocardial infarction is developing on the basis of several risk-factors and co-morbidities such as obesity, diabetes, hypertension, and hypercholesterolemia. Ischemic heart disease is the leading cause of mortality worldwide, therefore, identification of drug targets for cardioprotection is of great clinical importance. Ischemic preconditioning, postconditionin...

Routine exercise is widely recognized as cardioprotective. Exercise induces a variety of effects within the cardiovasculature, including decreased mitochondrial damage and improved aerobic capacity. It has been generally thought that the transient increase in oxidative stress associated with exercise initiates cardioprotective processes. Somewhat paradoxically, increased oxidative stress associ...

T ype 2 diabetes is associated with an excessive risk of cardiovascular events (1). On the other hand, physical activity reduces cardiovascular morbidity in diabetic patients (2). Resistin and numerous inflammatory markers (e.g., high-sensitivity C-reactive protein [hsCRP], interleukin [IL]-6, and IL-18) have emerged as novel predictors of cardiovascular diseases (3–5). We hypothesized that exe...

There had been no effective cardioprotective medications for heart failure with preserved ejection fraction (HFpEF). Therefore, treatment intervention at the hypertension (HT) stage (stage A), which is a major factor in HFpEF, necessary. In fact, SPRINT and STEP trials reported that strict intensive blood pressure (BP) control was useful, reducing approximately 25% of primary endpoints, includi...

some adipocytokines are cardioprotective or pro-inflammatory for cardiovascular system. chronic infection with chlamydia pneumoniae and helicobacter pylori has been also considered as novel risk factors for atherosclerosis. the main aim of the current population-based study is to investigate the potential link between circulating adipocytokines and chlamydia pneumoniae or helicobacter pylori ig...

OBJECTIVE The identification of sex-based disparities in the use of effective medications in high-risk populations can lead to interventions to minimize disparities in health outcomes. The objective of this study was to determine sex-specific rates of cardioprotective medication use in a large population-level administrative-health database from a universal-payer environment. RESEARCH DESIGN ...

BACKGROUND Recent evidence from Eastern Europe of a positive association between alcohol and cardiovascular disease has challenged the prevailing view that drinking is cardioprotective. Consuming amounts of alcohol comparable to those consumed in France has been linked to detrimental cardiovascular effects. One possibility is that this could be related to the particular consequences of binge dr...